Phenotypes associated with this allele

• Allele Symbol: Fbxl19^tm1.2Hko
• Allele Name: targeted mutation 1.2, Haruhiko Koseki
• Allele ID: MGI:6838372
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fbxl19^tm1.2Hko/Fbxl19^tm1.2Hko	involves: 129 * C57BL/6	MGI:6838373

Genotype
MGI:6838373

hm1

• Allelic Composition: Fbxl19^tm1.2Hko/Fbxl19^tm1.2Hko
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:316372 )

• no newborn mice are recovered

• however, mice are present at E10.5 in Mendelian ratios

embryo

abnormal first pharyngeal arch morphology ( J:316372 )

• at E10.5

embryonic growth retardation ( J:316372 )

• at E10.5 facial mesenchyme

small limb buds ( J:316372 )

• at E10.5

abnormal head mesenchyme morphology ( J:316372 )

• underdeveloped facial mesenchyme at E10.5

craniofacial

abnormal first pharyngeal arch morphology ( J:316372 )

• at E10.5

cardiovascular system

abnormal cardiac mesenchyme morphology ( J:316372 )

• hypomorphic

growth/size/body

embryonic growth retardation ( J:316372 )

• at E10.5 facial mesenchyme

abnormal head mesenchyme morphology ( J:316372 )

• underdeveloped facial mesenchyme at E10.5

delayed head development ( J:316372 )

• at E10.5

decreased body length ( J:316372 )

• at E10.5

limbs/digits/tail

small limb buds ( J:316372 )

• at E10.5