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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rr96+
wild type
MGI:6835802
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Rr96tm1.1Tich/Rr96+
Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sortm1(rtTA*M2)Jae 		involves: 129 * 129S4/SvJae * C57BL/6 MGI:5470231
cx2
 		Rr96tm2Litt/Rr96+
Zbtb7btm1.1Tani/Zbtb7btm1.1Tani 		involves: 129 * 129P2/OlaHsd * C57BL/6 MGI:3817577
cx3
 		Rr96tm2Litt/Rr96+
Zbtb7btm1Itan/Zbtb7btm1.1Tani 		involves: 129 * 129P2/OlaHsd * C57BL/6 MGI:3817581
cx4
 		Rr96tm1.1Tich/Rr96+
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+ 		involves: 129 * 129S4/SvJae * C57BL/6 MGI:5470229


Genotype
MGI:5470231
cn1
Allelic
Composition		 Rr96tm1.1Tich/Rr96+
Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic
Background		 involves: 129 * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(cre/ERT2)Thl mutation (0 available); any Gt(ROSA)26Sor mutation (1062 available)
Gt(ROSA)26Sortm1(rtTA*M2)Jae mutation (32 available); any Gt(ROSA)26Sor mutation (1062 available)
Rr96tm1.1Tich mutation (0 available); any Rr96 mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell differentiation ( J:191711 )
• derepression of Cd4 occurs in all CD4- T cells
• T cell expression of CD4 increases rapidly after cre activation

hematopoietic system
abnormal T cell differentiation ( J:191711 )
• derepression of Cd4 occurs in all CD4- T cells
• T cell expression of CD4 increases rapidly after cre activation




Genotype
MGI:3817577
cx2
Allelic
Composition		 Rr96tm2Litt/Rr96+
Zbtb7btm1.1Tani/Zbtb7btm1.1Tani
Genetic
Background		 involves: 129 * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr96tm2Litt mutation (0 available); any Rr96 mutation (0 available)
Zbtb7btm1.1Tani mutation (1 available); any Zbtb7b mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased double-negative T cell number ( J:141142 )
• virtually all T cells found in the lymph node are double-positive T cells

immune system
increased double-negative T cell number ( J:141142 )
• virtually all T cells found in the lymph node are double-positive T cells




Genotype
MGI:3817581
cx3
Allelic
Composition		 Rr96tm2Litt/Rr96+
Zbtb7btm1Itan/Zbtb7btm1.1Tani
Genetic
Background		 involves: 129 * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr96tm2Litt mutation (0 available); any Rr96 mutation (0 available)
Zbtb7btm1.1Tani mutation (1 available); any Zbtb7b mutation (26 available)
Zbtb7btm1Itan mutation (0 available); any Zbtb7b mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal double-negative T cell morphology ( J:141142 )
• the increase in double negative T cells observed in Zbtb7btm1Itan / Zbtb7btm1Tani compound heterozygotes is not observed in these mice
decreased CD8-positive, alpha-beta T cell number ( J:141142 )
• CD8+ T cells are almost absent in the periphery

hematopoietic system
abnormal double-negative T cell morphology ( J:141142 )
• the increase in double negative T cells observed in Zbtb7btm1Itan / Zbtb7btm1Tani compound heterozygotes is not observed in these mice
decreased CD8-positive, alpha-beta T cell number ( J:141142 )
• CD8+ T cells are almost absent in the periphery




Genotype
MGI:5470229
cx4
Allelic
Composition		 Rr96tm1.1Tich/Rr96+
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129 * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(rtTA*M2)Jae mutation (32 available); any Gt(ROSA)26Sor mutation (1062 available)
Rr96tm1.1Tich mutation (0 available); any Rr96 mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal CD4-positive T cell differentiation ( J:191711 )
• 15 days of doxycycline exposure leads to CD4 induction in all but the earliest CD4- thymocytes (not in DN1-3)
• only about 30% of peripheral CD8 cells begin expressing CD4

hematopoietic system
abnormal CD4-positive T cell differentiation ( J:191711 )
• 15 days of doxycycline exposure leads to CD4 induction in all but the earliest CD4- thymocytes (not in DN1-3)
• only about 30% of peripheral CD8 cells begin expressing CD4




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory