All Phenotypes Mirc13<tm1Biat> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mirc13^tm1Biat
targeted mutation 1, Biomodels Austria
MGI:6828804

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mirc13^tm1Biat/Mirc13^tm1Biat	involves: C57BL/6J * C57BL/6N	MGI:6829618
cn2	Mirc13^tm1Biat/Mirc13^tm1Biat Mirc4^tm1.1Biat/Mirc4^tm1.1Biat Tg(Ins2-cre)23Herr/0	involves: C57BL/6J * C57BL/6N * CBA/J	MGI:6829615
cn3	Mirc13^tm1Biat/Mirc13⁺ Mirc4^tm1.1Biat/Mirc4^tm1.1Biat Tg(Ins2-cre)23Herr/0	involves: C57BL/6J * C57BL/6N * CBA/J	MGI:6829617

Allelic Composition	Mirc13^tm1Biat/Mirc13^tm1Biat
Genetic Background	involves: C57BL/6J * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc13^tm1Biat mutation (0 available); any Mirc13 mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:314874 )

N	• mice exhibit normal weight when fed standard chow or a high-fat diet

abnormal glucose homeostasis ( J:314874 )

N	• mice exhibit normal glucose tolerance when fed standard chow or a high-fat diet

abnormal circulating glucose level ( J:314874 )

• streptozotocin-treated mice exhibit increased glucose serum levels that is not as severe as in wild-type mice

• mice treated with STZ and fed a high-fat diet exhibit a normal hyperglycemic response

decreased physiological sensitivity to xenobiotic ( J:314874 )

• mice treated with streptozotocin exhibit a mild increase in beta cell apoptosis and glucose serum levels compared with similarly treated wild-type mice

• mice treated with STZ and fed a high-fat diet exhibit a normal hyperglycemic response

endocrine/exocrine glands

abnormal pancreatic beta cell apoptosis ( J:314874 )

• streptozotocin-treated mice exhibit reduced apoptosis compared with controls but not as much as in double null mice

growth/size/body

decreased susceptibility to diet-induced obesity ( J:314874 )

N	• mice exhibit normal weight when fed standard chow or a high-fat diet

cellular

abnormal pancreatic beta cell apoptosis ( J:314874 )

• streptozotocin-treated mice exhibit reduced apoptosis compared with controls but not as much as in double null mice

Allelic Composition	Mirc13^tm1Biat/Mirc13^tm1Biat Mirc4^tm1.1Biat/Mirc4^tm1.1Biat Tg(Ins2-cre)23Herr/0
Genetic Background	involves: C57BL/6J * C57BL/6N * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc13^tm1Biat mutation (0 available); any Mirc13 mutation (3 available)
Mirc4^tm1.1Biat mutation (0 available); any Mirc4 mutation (1 available)
Tg(Ins2-cre)23Herr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:314874 )

N	• mice exhibit normal glucose tolerance when fed standard chow or a high-fat diet

abnormal circulating glucose level ( J:314874 )

• streptozotocin-treated mice exhibit increased glucose serum levels that is not as severe as in wild-type mice

• however, mice treated with STZ and fed a high-fat diet exhibit a normal hyperglycemic response

decreased physiological sensitivity to xenobiotic ( J:314874 )

• mice treated with streptozotocin exhibit a mild increase in beta cell apoptosis and glucose serum levels compared with similarly treated wild-type mice

• however, mice treated with STZ and fed a high-fat diet exhibit a normal hyperglycemic response

endocrine/exocrine glands

abnormal pancreatic beta cell apoptosis ( J:314874 )

• streptozotocin-treated mice exhibit reduced apoptosis compared with controls but not as much as in double null mice

growth/size/body

growth/size/body region phenotype ( J:314874 )

N	• mice exhibit normal weight when fed standard chow or a high-fat diet

cellular

abnormal pancreatic beta cell apoptosis ( J:314874 )

• streptozotocin-treated mice exhibit reduced apoptosis compared with controls but not as much as in double null mice

Allelic Composition	Mirc13^tm1Biat/Mirc13⁺ Mirc4^tm1.1Biat/Mirc4^tm1.1Biat Tg(Ins2-cre)23Herr/0
Genetic Background	involves: C57BL/6J * C57BL/6N * CBA/J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:314874 )

N	• streptozotocin-treated mice develop hyperglycemia as in wild-type mice

abnormal circulating glucose level ( J:314874 )

• streptozotocin-treated mice exhibit increased glucose serum levels that is not as severe as in wild-type mice

decreased physiological sensitivity to xenobiotic ( J:314874 )

• streptozotocin-treated mice exhibit reduced apoptosis and elevation of glucose serum levels compared with controls but not as much as in double null mice

endocrine/exocrine glands

abnormal pancreatic beta cell apoptosis ( J:314874 )

• streptozotocin-treated mice exhibit reduced apoptosis compared with controls but not as much as in double null mice

cellular

abnormal pancreatic beta cell apoptosis ( J:314874 )

• streptozotocin-treated mice exhibit reduced apoptosis compared with controls but not as much as in double null mice

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