Phenotypes associated with this allele

• Allele Symbol: Phf19^tm1.1Ldc
• Allele Name: targeted mutation 1.1, Luciano Di Croce
• Allele ID: MGI:6827412
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Phf19^tm1.1Ldc/Phf19^tm1.1Ldc	Not Specified	MGI:6827417

Genotype
MGI:6827417

hm1

• Allelic Composition: Phf19^tm1.1Ldc/Phf19^tm1.1Ldc
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

enlarged spleen ( J:313068 )

• after 60 weeks

impaired hematopoiesis ( J:313068 )

• long-term aberrant hematopoiesis

decreased bone marrow cell number ( J:313068 )

decreased hematopoietic cell number ( J:313068 )

• in adult mice

increased hematopoietic cell number ( J:313068 )

• at E14.5

abnormal hematopoietic stem cell physiology ( J:313068 )

• stem cell deletion after serial transplantation

• however, hematopoietic stem cells mobilize and proliferate upon stress

increased hematopoietic stem cell proliferation ( J:313068 )

• but lower differentiation capacity upon stress with 5-fluorouracil

skeleton

increased rib number ( J:313068 )

• in 6 of 14 mice

vertebral transformation ( J:313068 )

• anterior to posterior

growth/size/body

enlarged spleen ( J:313068 )

• after 60 weeks

immune system

enlarged spleen ( J:313068 )

• after 60 weeks

cellular

increased hematopoietic stem cell proliferation ( J:313068 )

• but lower differentiation capacity upon stress with 5-fluorouracil