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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Garin1aem1Osb
endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
MGI:6825733
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Garin1aem1Osb/Garin1aem1Osb involves: C57BL/6NJcl * DBA/2NJcl MGI:6827134


Genotype
MGI:6827134
hm1
Allelic
Composition		 Garin1aem1Osb/Garin1aem1Osb
Genetic
Background		 involves: C57BL/6NJcl * DBA/2NJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Garin1aem1Osb mutation (0 available); any Garin1a mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal sperm head morphology ( J:314135 )
• mild hook-like structures at the apical sperm head
abnormal acrosome morphology ( J:314135 )
• slightly expanded crescent shape
• however, mitochondria morphology is normal
impaired fertilization ( J:314135 )
• decreased fertilization of cumulus-intact and cumulus-free oocytes
• however, fertilization of zona pellucida-free oocytes is normal

cellular
abnormal sperm head morphology ( J:314135 )
• mild hook-like structures at the apical sperm head
abnormal acrosome morphology ( J:314135 )
• slightly expanded crescent shape
• however, mitochondria morphology is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory