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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cirbilem1Cya
endonuclease-mediated mutation 1, Cyagen Biosciences
MGI:6822319
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cirbilem1Cya/Cirbilem1Cya Not Specified MGI:6828947


Genotype
MGI:6828947
hm1
Allelic
Composition		 Cirbilem1Cya/Cirbilem1Cya
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased cardiac muscle contractility ( J:301260 )
• following ischemia/reperfusion injury
• however, knockdown of Bclaf1 via adenoviral expressing CRISPR-targeting Bclaf1 restores wild-type response
increased cardiomyocyte apoptosis ( J:301260 )
• following ischemia/reperfusion injury
• however, knockdown of Bclaf1 via adenoviral expressing CRISPR-targeting Bclaf1 restores wild-type response
increased myocardial infarct size ( J:301260 )
• following ischemia/reperfusion injury
• however, knockdown of Bclaf1 via adenoviral expressing CRISPR-targeting Bclaf1 restores wild-type response

homeostasis/metabolism
increased myocardial infarct size ( J:301260 )
• following ischemia/reperfusion injury
• however, knockdown of Bclaf1 via adenoviral expressing CRISPR-targeting Bclaf1 restores wild-type response
increased circulating lactate dehydrogenase level ( J:301260 )
• more than in control mice following ischemia/reperfusion injury

cellular
increased cardiomyocyte apoptosis ( J:301260 )
• following ischemia/reperfusion injury
• however, knockdown of Bclaf1 via adenoviral expressing CRISPR-targeting Bclaf1 restores wild-type response

muscle
decreased cardiac muscle contractility ( J:301260 )
• following ischemia/reperfusion injury
• however, knockdown of Bclaf1 via adenoviral expressing CRISPR-targeting Bclaf1 restores wild-type response
increased cardiomyocyte apoptosis ( J:301260 )
• following ischemia/reperfusion injury
• however, knockdown of Bclaf1 via adenoviral expressing CRISPR-targeting Bclaf1 restores wild-type response




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/21/2024
MGI 6.23 		The Jackson Laboratory