All Phenotypes Rprd1b<tm1Tshu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rprd1b^tm1Tshu
targeted mutation 1, Tsinghua University
MGI:6818638

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rprd1b^tm1Tshu/Rprd1b^tm1Tshu Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺ Tg(Vil1-cre)20Syr/0	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:6822318
cn2	Rprd1b^tm1Tshu/Rprd1b^tm1Tshu Tg(Vil1-cre)20Syr/0	involves: C57BL/6 * DBA/2	MGI:6822317

Allelic Composition	Rprd1b^tm1Tshu/Rprd1b^tm1Tshu Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺ Tg(Vil1-cre)20Syr/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgr5^{tm1(cre/ERT2)Cle} mutation (1 available); any Lgr5 mutation (57 available)
Rprd1b^tm1Tshu mutation (0 available); any Rprd1b mutation (16 available)
Tg(Vil1-cre)20Syr mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal digestive system development ( J:300857 )

• decreased Lgr5-GFP+ cells pre and post tamoxifen treatment

• tamoxifen-treated cultured intestinal crypt organoids exhibit fewer outgrowths and fail to reform after disaggregation unlike control cultures

Allelic Composition	Rprd1b^tm1Tshu/Rprd1b^tm1Tshu Tg(Vil1-cre)20Syr/0
Genetic Background	involves: C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rprd1b^tm1Tshu mutation (0 available); any Rprd1b mutation (16 available)
Tg(Vil1-cre)20Syr mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to colitis induced morbidity/mortality ( J:300857 )

• all DSS treated mice unlike similarly treated control mice

prenatal lethality, incomplete penetrance ( J:300857 )

• fewer than expected mice are born

digestive/alimentary system

digestive/alimentary phenotype ( J:300857 )

N	• mice exhibit normal villus number and structure in the small intestine

abnormal small intestine goblet cell morphology ( J:300857 )

• reduced number

abnormal digestive system development ( J:300857 )

• impaired proliferation and differentiation of Lgr5+ stem cells

abnormal large intestine crypts of Lieberkuhn morphology ( J:300857 )

• enlarged and thickened

abnormal large intestine goblet cell morphology ( J:300857 )

• reduced number

decreased Paneth cell number ( J:300857 )

• fewer lysozyme positive Paneth cells

impaired intestine regeneration ( J:300857 )

• failure to regenerated colon crypts after X-ray damage

increased susceptibility to colitis induced morbidity/mortality ( J:300857 )

• all DSS treated mice unlike similarly treated control mice

growth/size/body

decreased body weight ( J:300857 )

• in surviving mice

homeostasis/metabolism

impaired wound healing ( J:300857 )

• failure to regenerated colon crypts after X-ray damage

immune system

increased susceptibility to colitis induced morbidity/mortality ( J:300857 )

• all DSS treated mice unlike similarly treated control mice

cellular

abnormal large intestine goblet cell morphology ( J:300857 )

• reduced number

abnormal small intestine goblet cell morphology ( J:300857 )

• reduced number

endocrine/exocrine glands

abnormal large intestine crypts of Lieberkuhn morphology ( J:300857 )

• enlarged and thickened

abnormal large intestine goblet cell morphology ( J:300857 )

• reduced number

decreased Paneth cell number ( J:300857 )

• fewer lysozyme positive Paneth cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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