Phenotypes associated with this allele

• Allele Symbol: Atp5if1^em1Jpy
• Allele Name: endonuclease-mediated mutation 1, Jianping Ye
• Allele ID: MGI:6792081
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Atp5if1^em1Jpy/Atp5if1^em1Jpy	C57BL/6J-Atp5if1^em1Jpy	MGI:7255036

Genotype
MGI:7255036

hm1

• Allelic Composition: Atp5if1^em1Jpy/Atp5if1^em1Jpy
• Genetic Background: C57BL/6J-Atp5if1^em1Jpy

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased epididymal fat pad weight ( J:313048 )

♂ • when fed high-fat diet (HFD)

digestive/alimentary system

decreased enterocyte apoptosis ( J:313048 )

♀ • decreased apoptosis in colon tissue and epithelium when fed high-fat diet (HFD)

abnormal enterocyte morphology ( J:313048 )

♀ • smaller mitochondria with higher matrix density in colon when fed high-fat diet (HFD)

♀ • healthier villi with uniform length in colon when fed high-fat diet (HFD)

abnormal colon morphology ( J:313048 )

♀ • thicker intestinal wall with increased smooth muscle and mucosal layers when fed high-fat diet (HFD)

decreased susceptibility to colitis induced morbidity/mortality ( J:312819 )

• reduced severity of DSS-induced colitis: less body weight loss, lower disease activity index (DAI) and reduced colon atrophy (reduced damage to colon crypts and mucosal structures and lower histology severity score)

• reduced inflammatory macrophage and neutrophil infiltration of colon during DSS-induced colitis

• improved barrier function: reduced Salmonella invasion (orally inoculated) of intestine during DSS-induced colitis

hematopoietic system

hematopoietic system phenotype ( J:312819 )

N • normal blood macrophage and T cell numbers during DSS-induced colitis

decreased neutrophil cell number ( J:312819 )

• reduced blood neutrophil numbers during DSS-induced colitis

liver/biliary system

increased liver weight ( J:313048 )

♀ • when fed high-fat diet (HFD)

cellular

abnormal mitochondrial matrix morphology ( J:313048 )

♀ • higher matrix density in colon enterocytes when fed high-fat diet (HFD)

decreased mitochondrial size ( J:313048 )

♀ • in colon enterocytes when fed high-fat diet (HFD)

abnormal mitophagy ( J:313048 )

♀ • increased in colon enterocytes when fed high-fat diet (HFD)

decreased enterocyte apoptosis ( J:313048 )

♀ • decreased apoptosis in colon tissue and epithelium when fed high-fat diet (HFD)

immune system

decreased susceptibility to colitis induced morbidity/mortality ( J:312819 )

• reduced severity of DSS-induced colitis: less body weight loss, lower disease activity index (DAI) and reduced colon atrophy (reduced damage to colon crypts and mucosal structures and lower histology severity score)

• reduced inflammatory macrophage and neutrophil infiltration of colon during DSS-induced colitis

• improved barrier function: reduced Salmonella invasion (orally inoculated) of intestine during DSS-induced colitis

decreased neutrophil cell number ( J:312819 )

• reduced blood neutrophil numbers during DSS-induced colitis

growth/size/body

increased susceptibility to diet-induced obesity ( J:313048 , J:313048 )

• higher body weight gain when fed high-fat diet (HFD) (J:313048)

• higher body fat mass and larger liver when fed high-fat diet (HFD) (J:313048)

♂ • higher epididymal fat pad mass when fed high-fat diet (HFD) (J:313048)

increased liver weight ( J:313048 )

♀ • when fed high-fat diet (HFD)

mortality/aging

decreased susceptibility to colitis induced morbidity/mortality ( J:312819 )

• reduced severity of DSS-induced colitis: less body weight loss, lower disease activity index (DAI) and reduced colon atrophy (reduced damage to colon crypts and mucosal structures and lower histology severity score)

• reduced inflammatory macrophage and neutrophil infiltration of colon during DSS-induced colitis

• improved barrier function: reduced Salmonella invasion (orally inoculated) of intestine during DSS-induced colitis

homeostasis/metabolism

abnormal mitophagy ( J:313048 )

♀ • increased in colon enterocytes when fed high-fat diet (HFD)

decreased energy expenditure ( J:313048 )

♀ • when fed high-fat diet (HFD)

increased susceptibility to diet-induced obesity ( J:313048 , J:313048 )

• higher body weight gain when fed high-fat diet (HFD) (J:313048)

• higher body fat mass and larger liver when fed high-fat diet (HFD) (J:313048)

♂ • higher epididymal fat pad mass when fed high-fat diet (HFD) (J:313048)

improved glucose tolerance ( J:313048 )

♀ • increased pancreatic insulin secretion when fed high-fat diet (HFD)

insulin resistance ( J:313048 )

♀ • increased insulin tolerance when fed high-fat diet (HFD)

♀ • reduced insulin sensitivity in liver and skeletal muscle when fed high-fat diet (HFD)

behavior/neurological

decreased locomotor activity ( J:313048 )

♀ • in day and night periods when fed high-fat diet (HFD)