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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ercc6l2em1Mengf
endonuclease-mediated mutation 1, Feilong Meng
MGI:6791389
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ercc6l2em1Mengf/Ercc6l2em1Mengf Not Specified MGI:6792082
cx2
 		Ercc6l2em1Mengf/Ercc6l2em1Mengf
Nhej1em1Mengf/Nhej1em1Mengf 		Not Specified MGI:6792083


Genotype
MGI:6792082
hm1
Allelic
Composition		 Ercc6l2em1Mengf/Ercc6l2em1Mengf
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ercc6l2em1Mengf mutation (0 available); any Ercc6l2 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:311900 )
N
• normal naive splenic B cell numbers and proliferation
• normal activation-induced cytidine deaminase (AID)-induced somatic hypermutation (SHM) in germinal centers of immunized mice
• normal distribution of pro-B (CD43+ B220+ IgM-), pre-B (CD43- B220+ IgM-), immature B (IgM+ B220-low) and recirculating B (IgM+ B220-hi) cells in bone marrow
• normal distribution of CD4- CD8-, CD4+ CD8+, CD4+ CD8- and CD4- CD8+ T cells in thymus
abnormal class switch recombination ( J:311900 )
• reduced ~50% in splenic B cells after stimulation with LPS or LPS+IL4
decreased T cell number ( J:311900 )
• ~50% reduction in thymus

hematopoietic system
abnormal class switch recombination ( J:311900 )
• reduced ~50% in splenic B cells after stimulation with LPS or LPS+IL4
decreased T cell number ( J:311900 )
• ~50% reduction in thymus

mortality/aging
mortality/aging ( J:311900 )
N
• viable




Genotype
MGI:6792083
cx2
Allelic
Composition		 Ercc6l2em1Mengf/Ercc6l2em1Mengf
Nhej1em1Mengf/Nhej1em1Mengf
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ercc6l2em1Mengf mutation (0 available); any Ercc6l2 mutation (38 available)
Nhej1em1Mengf mutation (0 available); any Nhej1 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system

immune system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory