Analysis Tools
mortality/aging
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• tamoxifen-treated mice infected with influenza virus lose more weight and die within 8 days compared to controls in which 30% survive at the end of the experiments
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• majority of mice treated with tamoxifen at 10-12 weeks of age for 5 days die within 10 days
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growth/size/body
weight loss
(
J:311140
)
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• mice show more body weight loss than controls after the first injection of tamoxifen
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behavior/neurological
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• tamoxifen-treated mice exhibit loss of appetite
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• tamoxifen-treated mice exhibit loss of motility
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digestive/alimentary system
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• tamoxifen-treated mice exhibit more severe dextran sulfate sodium (DSS)-induced colonic injury, with more weight loss, shorter colon length and more severe inflammation
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endocrine/exocrine glands
small thymus
(
J:311140
)
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• thymus is smaller in tamoxifen-treated mice
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hematopoietic system
small thymus
(
J:311140
)
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• thymus is smaller in tamoxifen-treated mice
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• tamoxifen-treated mice infected with influenza virus exhibit increased number of neutrophils or alveolar macrophages in the lungs
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• tamoxifen-treated mice infected with influenza virus exhibit increased number of alveolar macrophages in the lungs
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• tamoxifen treated mice show a decrease in the number of white blood cells
• however, no effect on numbers of red blood cells or platelets is seen
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• total number and the percentage of lymphocytes is decreased in peripheral blood cells of tamoxifen-treated mice
• tamoxifen-treated mice show a decrease in lymphocytes in the spleen and thymus
• percentage of CD4+ and CD8+ lymphocytes is reduced in lungs of tamoxifen-treated influenza A virus infected mice
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• tamoxifen-treated mice infected with influenza A virus show decreased natural killer cells in the lungs compared to controls
• tamoxifen-treated mice infected with influenza A show decreased number of IFN-gamma+ and CD107a+ natural killer cells indicating impaired infiltration of natural killer cells and their function in the lung in response to influenza A infection
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small spleen
(
J:311140
)
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• spleen is smaller in tamoxifen-treated mice
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immune system
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• tamoxifen-treated mice exhibit more severe dextran sulfate sodium (DSS)-induced colonic injury, with more weight loss, shorter colon length and more severe inflammation
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small thymus
(
J:311140
)
|
• thymus is smaller in tamoxifen-treated mice
|
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• tamoxifen-treated mice infected with influenza virus exhibit increased number of neutrophils or alveolar macrophages in the lungs
|
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• tamoxifen-treated mice infected with influenza virus exhibit increased number of alveolar macrophages in the lungs
|
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• tamoxifen treated mice show a decrease in the number of white blood cells
• however, no effect on numbers of red blood cells or platelets is seen
|
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• total number and the percentage of lymphocytes is decreased in peripheral blood cells of tamoxifen-treated mice
• tamoxifen-treated mice show a decrease in lymphocytes in the spleen and thymus
• percentage of CD4+ and CD8+ lymphocytes is reduced in lungs of tamoxifen-treated influenza A virus infected mice
|
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• tamoxifen-treated mice infected with influenza A virus show decreased natural killer cells in the lungs compared to controls
• tamoxifen-treated mice infected with influenza A show decreased number of IFN-gamma+ and CD107a+ natural killer cells indicating impaired infiltration of natural killer cells and their function in the lung in response to influenza A infection
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small spleen
(
J:311140
)
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• spleen is smaller in tamoxifen-treated mice
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• tamoxifen-treated mice infected with pseudorabies virus show increased percentages of neutrophils, alveolar macrophages and monocytes in the lungs, indicating enhanced pulmonary inflammation in response to viral infection
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• tamoxifen-treated mice show increased susceptibility to influenza A virus, showing a higher degree of acute lung injury, more severe inflammation and inflammatory cell infiltration in the lungs, higher protein levels of viral NP in the lungs and increased viral titers in the lungs compared to controls
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• tamoxifen-treated mice infected with influenza virus lose more weight and die within 8 days compared to controls in which 30% survive at the end of the experiments
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integument
matted coat
(
J:311140
)
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• tamoxifen-treated mice exhibit matted hairs
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respiratory system
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• tamoxifen-treated mice infected with pseudorabies virus show increased percentages of neutrophils, alveolar macrophages and monocytes in the lungs, indicating enhanced pulmonary inflammation in response to viral infection
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