Phenotypes associated with this allele

• Allele Symbol: Tg(Prnp-UBQLN2*P506T)#Hlp
• Allele Name: transgene insertion, Henry L Paulson
• Allele ID: MGI:6784048
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Prnp-UBQLN2*P506T)#Hlp/0	involves: C57BL/6 * SJL	MGI:6790275

Genotype
MGI:6790275

tg1

• Allelic Composition: Tg(Prnp-UBQLN2*P506T)#Hlp/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

vision/eye phenotype ( J:299301 )

• normal eye morphology at ages 3 and 8 weeks

• normal retinal inner nuclear layer at age 12 months

thin retina outer nuclear layer ( J:299301 )

• significant thinning at age 9 months, progressively thinner at age 12 months

• normal at ages 3 and 8 weeks

cellular

cellular phenotype ( J:299301 )

• normal autophagy in brain

nervous system

nervous system phenotype ( J:299301 )

• normal brain lateral ventricular volume at age 18 months

behavior/neurological

behavior/neurological phenotype ( J:299301 )

• normal behavior in open field, balance beam and rotarod tests

• normal behavior in Morris water maze and fear conditioning tests