Phenotypes associated with this allele

• Allele Symbol: Srsf5^em1Nju
• Allele Name: endonuclease-mediated mutation 1, Model Animal Research Center of Nanjing University
• Allele ID: MGI:6782384
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Srsf5^em1Nju/Srsf5^em1Nju	C57BL/6JGpt-Srsf5^em1Nju	MGI:6782840

Genotype
MGI:6782840

hm1

• Allelic Composition: Srsf5^em1Nju/Srsf5^em1Nju
• Genetic Background: C57BL/6JGpt-Srsf5^em1Nju

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:311867 )

• most mice die within 24 h of birth without breathing

postnatal lethality, complete penetrance ( J:311867 )

• all mice die by P2

cardiovascular system

abnormal ventricle myocardium morphology ( J:311867 )

• noncompaction with widening of the subendocardial intermuscular space and vacuolar degeneration of some cardiomyocytes at E8.5 and P1

abnormal trabecula carnea morphology ( J:311867 )

• long and densely arranged

thin ventricle myocardium compact layer ( J:311867 )

• in both ventricles

abnormal heart left ventricle morphology ( J:311867 )

• increased internal diameter and left ventricular volume during systole

decreased heart left ventricle wall thickness ( J:311867 )

• during diastole and systole in the left ventricle

abnormal heart right ventricle morphology ( J:311867 )

• protruding apex at birth

decreased cardiac muscle contractility ( J:311867 )

decreased fetal cardiomyocyte proliferation ( J:311867 )

• at P1

• however, no increase in apoptosis is observed

decreased left ventricle systolic pressure ( J:311867 )

• in surviving mice at P1

decreased heart rate ( J:311867 )

• extremely low

atrioventricular block ( J:311867 )

• light implied by prolonged PR and QT intervals

prolonged PR interval ( J:311867 )

decreased QRS amplitude ( J:311867 )

• extremely low

prolonged QT interval ( J:311867 )

growth/size/body

decreased birth body size ( J:311867 )

respiratory system

primary atelectasis ( J:311867 )

• mice that die at birth do not breath

behavior/neurological

absent gastric milk in neonates ( J:311867 )

integument

pallor ( J:311867 )

• in surviving mice at P1

immune system

small spleen ( J:311867 )

• at birth

muscle

abnormal ventricle myocardium morphology ( J:311867 )

• noncompaction with widening of the subendocardial intermuscular space and vacuolar degeneration of some cardiomyocytes at E8.5 and P1

abnormal trabecula carnea morphology ( J:311867 )

• long and densely arranged

thin ventricle myocardium compact layer ( J:311867 )

• in both ventricles

decreased cardiac muscle contractility ( J:311867 )

decreased fetal cardiomyocyte proliferation ( J:311867 )

• at P1

• however, no increase in apoptosis is observed

cellular

decreased fetal cardiomyocyte proliferation ( J:311867 )

• at P1

• however, no increase in apoptosis is observed

hematopoietic system

small spleen ( J:311867 )

• at birth