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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Spaca4em2Pauli
endonuclease-mediated mutation 2, Andrea Pauli
MGI:6766530
Summary 2 genotypes


Genotype
MGI:6771321
hm1
Allelic
Composition		 Spaca4em2Pauli/Spaca4em2Pauli
Genetic
Background		 C57BL/6J-Spaca4em2Pauli/Osb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spaca4em2Pauli mutation (0 available); any Spaca4 mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal sperm-egg fusion ( J:311165 )
• impaired sperm to egg binding




Genotype
MGI:6771323
ht2
Allelic
Composition		 Spaca4em1Pauli/Spaca4em2Pauli
Genetic
Background		 C57BL/6J-Spaca4em1Pauli/Spaca4em2Pauli
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spaca4em1Pauli mutation (0 available); any Spaca4 mutation (8 available)
Spaca4em2Pauli mutation (0 available); any Spaca4 mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:311165 )
N
• female mice exhibit normal fertility
decreased litter size ( J:311165 )
• male mice produce smaller litter sizes compared with wild-type mice
reduced male fertility ( J:311165 )
• male mice produce smaller litter sizes compared with wild-type mice
abnormal sperm-egg fusion ( J:311165 )
• impaired sperm to egg binding

cellular




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory