All Phenotypes Or55b10<tm1Tboz> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Or55b10^tm1Tboz
targeted mutation 1, Thomas Bozza
MGI:6766439

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Or55b10^tm1Tboz/Or55b10^tm1Tboz Rr82^em1Tboz/Rr82^em1Tboz	involves: 129S6/SvEv * C57BL/6J	MGI:6766459
cx2	Or55b10^tm1Tboz/Or55b10^tm1Tboz Rr86^em1Tboz/Rr86^em1Tboz	involves: 129S6/SvEv * C57BL/6J	MGI:6766460
cx3	Or55b10^tm1Tboz/Or55b10^tm1Tboz Rr87^em1Tboz/Rr87^em1Tboz	involves: 129S6/SvEv * C57BL/6J	MGI:6766461
cx4	Del(7)3Tboz/Del(7)3Tboz Or55b10^tm1Tboz/Or55b10^tm1Tboz	involves: 129S6/SvEv * C57BL/6J	MGI:6766462

Allelic Composition	Or55b10^tm1Tboz/Or55b10^tm1Tboz Rr82^em1Tboz/Rr82^em1Tboz
Genetic Background	involves: 129S6/SvEv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Or55b10^tm1Tboz mutation (0 available); any Or55b10 mutation (17 available)
Rr82^em1Tboz mutation (0 available); any Rr82 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

abnormal olfactory receptor morphology ( J:310034 )

• in the absence of this enhancer there is reduced expression of 70 out of 131 class I olfactory receptor genes, with expression of 18 of those receptors being abolished, and the effect correlates with genomic distance with no genes outside of the class I olfactory receptor cluster being affected

taste/olfaction

abnormal olfactory receptor morphology ( J:310034 )

• in the absence of this enhancer there is reduced expression of 70 out of 131 class I olfactory receptor genes, with expression of 18 of those receptors being abolished, and the effect correlates with genomic distance with no genes outside of the class I olfactory receptor cluster being affected

impaired olfaction ( J:310034 )

• homozygous loss of this enhancer results in a lack of aversion to carboxylic acids

nervous system

abnormal olfactory receptor morphology ( J:310034 )

• in the absence of this enhancer there is reduced expression of 70 out of 131 class I olfactory receptor genes, with expression of 18 of those receptors being abolished, and the effect correlates with genomic distance with no genes outside of the class I olfactory receptor cluster being affected

respiratory system

abnormal olfactory receptor morphology ( J:310034 )

• in the absence of this enhancer there is reduced expression of 70 out of 131 class I olfactory receptor genes, with expression of 18 of those receptors being abolished, and the effect correlates with genomic distance with no genes outside of the class I olfactory receptor cluster being affected

growth/size/body

abnormal olfactory receptor morphology ( J:310034 )

• in the absence of this enhancer there is reduced expression of 70 out of 131 class I olfactory receptor genes, with expression of 18 of those receptors being abolished, and the effect correlates with genomic distance with no genes outside of the class I olfactory receptor cluster being affected

Allelic Composition	Or55b10^tm1Tboz/Or55b10^tm1Tboz Rr86^em1Tboz/Rr86^em1Tboz
Genetic Background	involves: 129S6/SvEv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Or55b10^tm1Tboz mutation (0 available); any Or55b10 mutation (17 available)
Rr86^em1Tboz mutation (0 available); any Rr86 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

abnormal olfactory receptor morphology ( J:310034 )

• homozygous deletion of this enhancer does not decrease Olfr545 expression but does decrease expression of Olfr577

growth/size/body

abnormal olfactory receptor morphology ( J:310034 )

• homozygous deletion of this enhancer does not decrease Olfr545 expression but does decrease expression of Olfr577

nervous system

abnormal olfactory receptor morphology ( J:310034 )

• homozygous deletion of this enhancer does not decrease Olfr545 expression but does decrease expression of Olfr577

respiratory system

abnormal olfactory receptor morphology ( J:310034 )

• homozygous deletion of this enhancer does not decrease Olfr545 expression but does decrease expression of Olfr577

taste/olfaction

abnormal olfactory receptor morphology ( J:310034 )

• homozygous deletion of this enhancer does not decrease Olfr545 expression but does decrease expression of Olfr577

Allelic Composition	Or55b10^tm1Tboz/Or55b10^tm1Tboz Rr87^em1Tboz/Rr87^em1Tboz
Genetic Background	involves: 129S6/SvEv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Or55b10^tm1Tboz mutation (0 available); any Or55b10 mutation (17 available)
Rr87^em1Tboz mutation (0 available); any Rr87 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

abnormal olfactory receptor morphology ( J:310034 )

• homozygous deletion of this enhancer does not decrease Olfr545 expression but does decrease Olfr571 expression

growth/size/body

abnormal olfactory receptor morphology ( J:310034 )

• homozygous deletion of this enhancer does not decrease Olfr545 expression but does decrease Olfr571 expression

nervous system

abnormal olfactory receptor morphology ( J:310034 )

• homozygous deletion of this enhancer does not decrease Olfr545 expression but does decrease Olfr571 expression

respiratory system

abnormal olfactory receptor morphology ( J:310034 )

• homozygous deletion of this enhancer does not decrease Olfr545 expression but does decrease Olfr571 expression

taste/olfaction

abnormal olfactory receptor morphology ( J:310034 )

• homozygous deletion of this enhancer does not decrease Olfr545 expression but does decrease Olfr571 expression

Allelic Composition	Del(7)3Tboz/Del(7)3Tboz Or55b10^tm1Tboz/Or55b10^tm1Tboz
Genetic Background	involves: 129S6/SvEv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(7)3Tboz mutation (0 available); any Del(7)3Tboz mutation (0 available)
Or55b10^tm1Tboz mutation (0 available); any Or55b10 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

abnormal olfactory receptor morphology ( J:310034 )

• 77 of the intact class I olfactory receptor genes have reduced expression

growth/size/body

abnormal olfactory receptor morphology ( J:310034 )

• 77 of the intact class I olfactory receptor genes have reduced expression

nervous system

abnormal olfactory receptor morphology ( J:310034 )

• 77 of the intact class I olfactory receptor genes have reduced expression

respiratory system

abnormal olfactory receptor morphology ( J:310034 )

• 77 of the intact class I olfactory receptor genes have reduced expression

taste/olfaction

abnormal olfactory receptor morphology ( J:310034 )

• 77 of the intact class I olfactory receptor genes have reduced expression

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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