Phenotypes associated with this allele

• Allele Symbol: Habp4^em1Jkob
• Allele Name: endonuclease-mediated mutation 1, Jorg Kobarg
• Allele ID: MGI:6763956
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Habp4^em1Jkob/Habp4^em1Jkob	involves: C57BL/6J	MGI:6763961

Genotype
MGI:6763961

hm1

• Allelic Composition: Habp4^em1Jkob/Habp4^em1Jkob
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal intestinal epithelium physiology ( J:310581 )

• colons exhibit increased proliferation in the colon epithelia

• colon crypt cells exhibit a higher rate of proliferation at the bottom of the crypt coupled to faster turnover of the epithelial colon cells

• however, colon crypt organization is not grossly altered

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:310581 )

• mice treated with the carcinogen azoxymethane (AOM) followed by dextran sodium sulfate (DSS) exhibit a higher number of tumors and larger tumors than in wild-type mice

neoplasm

increased incidence of tumors by chemical induction ( J:310581 )

• mice treated with the carcinogen azoxymethane (AOM) followed by dextran sodium sulfate (DSS) exhibit a higher number of tumors and larger tumors than in wild-type mice