Phenotypes associated with this allele

• Allele Symbol: Strada^em1Pbcr
• Allele Name: endonuclease-mediated mutation 1, Peter B Crino
• Allele ID: MGI:6758261
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Strada^em1Pbcr/Strada^em1Pbcr	C57BL/6N-Strada^em1Pbcr	MGI:6758503
ht2	Strada^em1Pbcr/Strada^+	C57BL/6N-Strada^em1Pbcr	MGI:6758504

Genotype
MGI:6758503

hm1

• Allelic Composition: Strada^em1Pbcr/Strada^em1Pbcr
• Genetic Background: C57BL/6N-Strada^em1Pbcr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:308972 )

• most mice die within the first 5 days after birth

nervous system

abnormal neuronal migration ( J:308972 )

• abnormal migration of late-born neurons

increased brain size ( J:308972 )

• however, gross structure of hemispheres is normal

enlarged brain ventricles ( J:308972 )

ectopic neuron ( J:308972 )

• Cux1+ neurons in the deeper layers or subcortical white matter

behavior/neurological

behavior/neurological phenotype ( J:308972 )

N • mice exhibit no obvious behavioral or motor phenotype

abnormal suckling behavior ( J:308972 )

• difficulty initiating and maintaining suckling

tremors ( J:308972 )

• when attempting to ambulate

decreased locomotor activity ( J:308972 )

• limited mobility in cage

growth/size/body

long incisors ( J:308972 )

malocclusion ( J:308972 )

• of incisors that interfere with successful feeding

decreased body size ( J:308972 )

skeleton

skeleton phenotype ( J:308972 )

N • mice exhibit normal anterior cruciate ligaments

long incisors ( J:308972 )

malocclusion ( J:308972 )

• of incisors that interfere with successful feeding

domed cranium ( J:308972 )

muscle

hypotonia ( J:308972 )

• with limited mobility in cage

craniofacial

long incisors ( J:308972 )

malocclusion ( J:308972 )

• of incisors that interfere with successful feeding

domed cranium ( J:308972 )

cellular

abnormal neuronal migration ( J:308972 )

• abnormal migration of late-born neurons

Genotype
MGI:6758504

ht2

• Allelic Composition: Strada^em1Pbcr/Strada⁺
• Genetic Background: C57BL/6N-Strada^em1Pbcr

reproductive system

reduced female fertility ( J:308972 )

♀ • female mice produce either smaller liters or no litters at all