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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Specc1ltm1Kumc
targeted mutation 1, University of Kansas Medical Center
MGI:6758246
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Specc1lem1Kumc/Specc1ltm1Kumc involves: 129S6/SvEvTac MGI:7354948


Genotype
MGI:7354948
ht1
Allelic
Composition
Specc1lem1Kumc/Specc1ltm1Kumc
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Specc1lem1Kumc mutation (0 available); any Specc1l mutation (51 available)
Specc1ltm1Kumc mutation (0 available); any Specc1l mutation (51 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

craniofacial
• at E14.5 the palatal shelves are acutely angled and do not move immediately inwards to occupy the space above the tongue
• during elevation the posterior plate advances prior to middle and anterior plates
• in culture, embryonic palatal mesenchyme cells show reduced migration speed of wound fronts, overall reduction in motile activity, and impaired guidance
• decrease in correlation length values in high density areas suggests impaired ability of palate mesenchymal cells to form streams
• delayed at E14.5 but in most cases shelves fuse by E15.5

digestive/alimentary system
• at E14.5 the palatal shelves are acutely angled and do not move immediately inwards to occupy the space above the tongue
• during elevation the posterior plate advances prior to middle and anterior plates
• in culture, embryonic palatal mesenchyme cells show reduced migration speed of wound fronts, overall reduction in motile activity, and impaired guidance
• decrease in correlation length values in high density areas suggests impaired ability of palate mesenchymal cells to form streams
• delayed at E14.5 but in most cases shelves fuse by E15.5

growth/size/body
• at E14.5 the palatal shelves are acutely angled and do not move immediately inwards to occupy the space above the tongue
• during elevation the posterior plate advances prior to middle and anterior plates
• in culture, embryonic palatal mesenchyme cells show reduced migration speed of wound fronts, overall reduction in motile activity, and impaired guidance
• decrease in correlation length values in high density areas suggests impaired ability of palate mesenchymal cells to form streams
• delayed at E14.5 but in most cases shelves fuse by E15.5





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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory