All Phenotypes Tg(Map1a)56Pjn MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Map1a)56Pjn
transgene insertion 56, Patsy Nishina
MGI:6753368

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(Map1a)56Pjn/0 Tub^tub/Tub^tub	B6(AU)-Tub^tub Tg(Map1a)56Pjn/Pjn	MGI:6753376
cx2	Tg(Map1a)56Pjn/0 Tulp1^tm1Pjn/Tulp1^tm1Pjn	B6.Cg-Tulp1^tm1Pjn Tg(Map1a)56Pjn/Pjn	MGI:6756408
cx3	Map1a^m1J/Map1a^m1J Tg(Map1a)56Pjn/0	involves: C57BL/6J * C57BLKS/J	MGI:6756405

Allelic Composition	Tg(Map1a)56Pjn/0 Tub^tub/Tub^tub
Genetic Background	B6(AU)-Tub^tub Tg(Map1a)56Pjn/Pjn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Map1a)56Pjn mutation (1 available)
Tub^tub mutation (3 available); any Tub mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal eye morphology ( J:196742 )

• Background Sensitivity: The presence of the 129P2/OlaHsd allele of Map1a from the transgene rescues some of the photoreceptor degeneration that occurs in tubby homozygotes on a predominantly C57BL/6J background, with an average of 126 photoreceptor nuclei remaining in the outer nuclear layer in the presence of the transgene but only 76 in the tubby homozygotes lacking this transgene

hearing/vestibular/ear

abnormal hearing physiology ( J:75815 )

• Background Sensitivity: The 129P2/OlaHsd-derived sequence of this transgene rescues much of the hearing loss phenotype of tubby homozygotes on the C57BL/6J background

Allelic Composition	Tg(Map1a)56Pjn/0 Tulp1^tm1Pjn/Tulp1^tm1Pjn
Genetic Background	B6.Cg-Tulp1^tm1Pjn Tg(Map1a)56Pjn/Pjn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Map1a)56Pjn mutation (1 available)
Tulp1^tm1Pjn mutation (1 available); any Tulp1 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal eye morphology ( J:196742 )

• The presence of the 129P2/OlaHsd allele of Map1a from the transgene rescues some of the photoreceptor degeneration that occurs in Tulp1 null homozygotes, with an average of 177 photoreceptor nuclei remaining in the outer nuclear layer in the presence of the transgene but only 112 in the tubby homozygotes lacking this transgene

Allelic Composition	Map1a^m1J/Map1a^m1J Tg(Map1a)56Pjn/0
Genetic Background	involves: C57BL/6J * C57BLKS/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map1a^m1J mutation (1 available); any Map1a mutation (109 available)
Tg(Map1a)56Pjn mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:220153 )

N	• Even at 18 months of age no locomotor defects or Purkinje cell loss was found consistent with transgenic rescue of the homozygous mutant phenotype

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