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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ppp2r2dem1Gct
endonuclease-mediated mutation 1, George C Tsokos
MGI:6731086
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ppp2r2dem1Gct/Ppp2r2dem1Gct
Tg(Lck-icre)3779Nik/0 		involves: C57BL/6 * DBA/2 MGI:6740222


Genotype
MGI:6740222
cn1
Allelic
Composition		 Ppp2r2dem1Gct/Ppp2r2dem1Gct
Tg(Lck-icre)3779Nik/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp2r2dem1Gct mutation (0 available); any Ppp2r2d mutation (310 available)
Tg(Lck-icre)3779Nik mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:308373 )
N
• normal T cell subset percentages and absolute numbers in thymus and spleen
• normal percentage of apoptotic double-negative and double-positive thymocytes after CD3 antibody stimulation
abnormal regulatory T cell physiology ( J:308373 )
• increased suppressive activity

immune system
abnormal regulatory T cell physiology ( J:308373 )
• increased suppressive activity
increased interleukin-2 secretion ( J:308373 )
• increased production in stimulated spleen CD4+ and CD8+ T cells

behavior/neurological
behavior/neurological phenotype ( J:308373 )
N
• normal behavior

growth/size/body
growth/size/body region phenotype ( J:308373 )
N
• normal size, no gross abnormalities

mortality/aging
mortality/aging ( J:308373 )
N
• viable

reproductive system




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory