Phenotypes associated with this allele

• Allele Symbol: Mir148a^tm2942.2Arte
• Allele Name: targeted mutation 2942.2, TaconicArtemis
• Allele ID: MGI:6731011
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mir148a^tm2942.2Arte/Mir148a^tm2942.2Arte	involves: C57BL/6 * FVB/N	MGI:6731091

Genotype
MGI:6731091

hm1

• Allelic Composition: Mir148a^tm2942.2Arte/Mir148a^tm2942.2Arte
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased plasma cell number ( J:307366 )

• mice exhibit a reduction in late CD19-negative P3 plasma cells in the bone marrow and spleen

abnormal B cell physiology ( J:307366 )

• mice show reduced maximal respiratory capacity and reduced non-mitochondrial oxygen consumption rate of LPS-activated B cell blasts

• the P2 and P3-plasma cell populations show a an approximate 10-30% and 40-50% reduction in glucose uptake in the spleen and bone marrow, respectively, compared to wild-type mice, indicating impaired glucose uptake in mature plasma cells

hematopoietic system

decreased plasma cell number ( J:307366 )

• mice exhibit a reduction in late CD19-negative P3 plasma cells in the bone marrow and spleen

abnormal B cell physiology ( J:307366 )

• mice show reduced maximal respiratory capacity and reduced non-mitochondrial oxygen consumption rate of LPS-activated B cell blasts

• the P2 and P3-plasma cell populations show a an approximate 10-30% and 40-50% reduction in glucose uptake in the spleen and bone marrow, respectively, compared to wild-type mice, indicating impaired glucose uptake in mature plasma cells

cellular

decreased cellular glucose uptake ( J:307366 )

• the P2 and P3-plasma cell populations show a an approximate 10-30% and 40-50% reduction in glucose uptake in the spleen and bone marrow, respectively, compared to wild-type mice, indicating impaired glucose uptake in mature plasma cells