Phenotypes associated with this allele

• Allele Symbol: Zfp217^em1Sjia
• Allele Name: endonuclease-mediated mutation 1, Siwen Jiang
• Allele ID: MGI:6730372
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zfp217^em1Sjia/Zfp217^em1Sjia	involves: C57BL/6J	MGI:6730373
ht2	Zfp217^em1Sjia/Zfp217^+	involves: C57BL/6J	MGI:6730374

Genotype
MGI:6730373

hm1

• Allelic Composition: Zfp217^em1Sjia/Zfp217^em1Sjia
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:307358 )

• embryonic lethal as no live mice are obtained

Genotype
MGI:6730374

ht2

• Allelic Composition: Zfp217^em1Sjia/Zfp217⁺
• Genetic Background: involves: C57BL/6J

growth/size/body

decreased susceptibility to diet-induced obesity ( J:307358 )

♂ • mice are resistant to diet-induced obesity, with mice showing slower weight gain on a high-fat diet

♂ • however, mice do not show a difference in food intake on a high-fat diet or in weight on a chow diet

adipose tissue

abnormal adipose tissue development ( J:307358 )

• mouse embryo fibroblasts (MEFs) induced in an adipogenic culture medium to differentiate into adipocytes show fewer lipid droplets and lower triglyceride content indicating decreased adipogenic potential and marker analysis indicates reduced adipogenesis

decreased fat cell size ( J:307358 )

♂ • mice fed a high-fat diet show a smaller average area and size distribution of adipocytes

decreased total fat pad weight ( J:307358 )

♂ • high-fat diet fed mice have lower fat weight and smaller iWAT and BAT pads

♂ • however, no differences in eWAT pads is seen on a high-fat diet

decreased percent body fat/body weight ( J:307358 )

♂ • high-fat diet fed mice have lower percentage total body fat

♂ • however, mice fed a chow diet show normal percentage total body fat

homeostasis/metabolism

increased energy expenditure ( J:307358 )

• mice exhibit increased energy expenditure in dark phases when fed a chow diet

• energy expenditure rate is increased during both light and dark phases in high-fat diet fed mice

decreased susceptibility to diet-induced obesity ( J:307358 )

♂ • mice are resistant to diet-induced obesity, with mice showing slower weight gain on a high-fat diet

♂ • however, mice do not show a difference in food intake on a high-fat diet or in weight on a chow diet

increased carbon dioxide production ( J:307358 )

♂ • total volume of carbon dioxide production (VCO2) is increased in high-fat diet fed mice during both light and dark phases

increased oxygen consumption ( J:307358 )

• mice exhibit increased oxygen consumption (VO2) in dark phases when fed a chow diet

• oxygen consumption is increased in high-fat diet fed mice during both light and dark phases

improved glucose tolerance ( J:307358 )

♂ • glucose tolerance test shows that mice fed a high-fat diet exhibit improved glucose clearance

♂ • however, mouse fed a chow diet show no differences in glucose tolerance from wild-type mice

increased insulin sensitivity ( J:307358 )

♂ • insulin tolerance test shows that mice fed a high-fat diet are more sensitive to insulin than willd-type mice

♂ • however, mouse fed a chow diet show no differences in insulin tolerance from wild-type mice