Phenotypes associated with this allele

• Allele Symbol: Tnf^em4Boui
• Allele Name: endonuclease-mediated mutation 4, Philippe Bouillet
• Allele ID: MGI:6729295
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnf^em4Boui/Tnf^em4Boui	C57BL/6-Tnf^em4Boui	MGI:6730102
ht2	Tnf^em4Boui/Tnf^+	C57BL/6-Tnf^em4Boui	MGI:6730101

Genotype
MGI:6730102

hm1

• Allelic Composition: Tnf^em4Boui/Tnf^em4Boui
• Genetic Background: C57BL/6-Tnf^em4Boui

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal embryo morphology ( J:306876 )

• pale heads, limbs and tails owing to disappearance of blood vessels

• 3x increase in proportion of nucleated erythroblasts at E16.5

• fragmentation of vascular system in limbs at E16.5

• normal appearance up to E15.5

decreased embryo size ( J:306876 )

• at E16.5

• normal size up to E15.5

growth/size/body

decreased embryo size ( J:306876 )

• at E16.5

• normal size up to E15.5

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:306876 )

• no live embryos after E16.5

Genotype
MGI:6730101

ht2

• Allelic Composition: Tnf^em4Boui/Tnf⁺
• Genetic Background: C57BL/6-Tnf^em4Boui

cardiovascular system

cardiovalvulitis ( J:306876 )

digestive/alimentary system

colitis ( J:306876 )

ileum inflammation ( J:306876 )

esophageal inflammation ( J:306876 )

immune system

cardiovalvulitis ( J:306876 )

colitis ( J:306876 )

ileum inflammation ( J:306876 )

esophageal inflammation ( J:306876 )

autoimmune arthritis ( J:306876 )

mortality/aging

premature death ( J:306876 )

• most mice die by age 250 days

skeleton

autoimmune arthritis ( J:306876 )