Analysis Tools
mortality/aging
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• neonatal mortality rate is increased, with 70.6% dying after birth compared to 29.1% of wild-type siblings
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behavior/neurological
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• mice exhibit decreased freezing time in cue-dependent fear-conditioning test
• however, freezing time in contextual fear-conditioning tests is not different
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• mutant mice take approximately half of total training trials that wild-type mice require to reach the criterion in the visual discrimination task
• however, no differences are seen in the reversal learning task and basal synaptic transmission is normal in layer 2/3 in the medial prefrontal cortex
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• the amplitude of startle response per se is higher than in wild-type mice
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• mice move shorter distance in the entire field and transit between the outer and inner zones less frequently in the open-field
• however, total locomotor activity in a test cage is not different, but activity for the first 5 minutes appears to be less
• however, no differences in rotarod and elevated-plus maze tests are seen, indicating normal anxiety-like behavior, motor coordination and learning, and no differences in exploration time and percentage of preference between familiar and novel objects in the novel object recognition test are seen
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• in the jet lag test, mutant mice adapt to a new light-dark cycle faster than wild-type mice when the phase is advanced, indicating that mice are more sensitive to an environmental light condition or that the robustness of the circadian clockwork is reduced
• however, free-running period is unaltered, vulnerability of sleep-wake cycle to the ambient light condition is unaltered
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• activity levels are reduced at around CT16 in constant dark condition, resulting in an emergence of a third peak between the evening and morning peaks, indicating that an intrinsic circadian rhythm is disturbed, but light-induced entrainment can adjust the disturbed behavioral rhythm
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• while no differences in trial 1-4 of the five-trial direct social interaction test is seen, mutant mice exhibit a reduction of the interaction time in trial 5 indicating a deficit in social recognition of a novel mouse
• however, mice show no differences in sociability and social novelty preference in the three-chamber test
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nervous system
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• mice show a reduction of auditory-dependent sensorimotor gating
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• auditory prepulse-mediated prepulse inhibition is decreased
• however, PPI test using light stimulation as a prepulse shows no difference from wild-type mice
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cardiovascular system
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• 10% of E18.5 mutants exhibit cardiovascular abnormalities, including interrupted aortic arch and aberrant right subclavian artery
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• seen in a small percentage of E18.5 mutants
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• aberrant right subclavian artery is seen in a small percentage of E18.5 mutants
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endocrine/exocrine glands
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• 45.7% of E18.5 mutants show hypoplasia of the thymus with an asymmetric appearance
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hematopoietic system
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• 45.7% of E18.5 mutants show hypoplasia of the thymus with an asymmetric appearance
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immune system
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• 45.7% of E18.5 mutants show hypoplasia of the thymus with an asymmetric appearance
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vision/eye
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• mice exhibit generally smaller visual-evoked potentials; the amplitudes of P1 and N2 peaks are smaller, however the latency to each peak is not different
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| chromosome 22q11.2 deletion syndrome, distal | DOID:0060413 |
OMIM:611867 |
J:285407 | |
