All Phenotypes Klhl17<em1Yph> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Klhl17^em1Yph
endonuclease-mediated mutation 1, Yi-Ping Hsueh
MGI:6728081

Summary

2 genotypes

Allelic Composition	Klhl17^em1Yph/Klhl17^em1Yph
Genetic Background	C57BL/6-Klhl17^em1Yph

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klhl17^em1Yph mutation (0 available); any Klhl17 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

• width of dendritic spine heads of neurons is reduced

• however, spine density and length are not altered

Allelic Composition	Klhl17^em1Yph/Klhl17⁺
Genetic Background	C57BL/6-Klhl17^em1Yph

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klhl17^em1Yph mutation (0 available); any Klhl17 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

• mice show reduced interaction with unfamiliar mice in reciprocal social interaction

increased vertical activity ( J:308069 )

• mice exhibit more frequent rearing behaviors in the open field

increased locomotor activity ( J:308069 )

• mice exhibit longer moving distances in the open field

• however, mice show no differences from wild-type in the elevated plus maze

nervous system

• width of dendritic spine heads of neurons is reduced

• however, spine density and length are not altered

• mEPSC amplitude of hippocampal neurons is slightly increased

• however, mEPSC frequency is normal

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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