Phenotypes associated with this allele

• Allele Symbol: TgTn(pb-CAG-Gm614)#Cya
• Allele Name: transgenic transposon concatemer, Cyagen Biosciences
• Allele ID: MGI:6727902
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	TgTn(pb-CAG-Gm614)#Cya/0	involves: C57BL/6	MGI:6727910

Genotype
MGI:6727910

tg1

• Allelic Composition: TgTn(pb-CAG-Gm614)#Cya/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:307345 )

N • normal total IgG levels after pristane injection

N • normal CD86^loCXCR4^hi dark zone (DZ) and CD86^hiCXCR4^lo light zone (LZ) B cells ratio after pristane injection

N • normal germinal center B cell cell cycle after pristane injection

decreased B cell apoptosis ( J:307345 )

• in germinal center after pristane injection

increased susceptibility to systemic lupus erythematosus ( J:307345 )

• increased inflammatory cell infiltration in kidney and increased kidney damage after pristane injection

• increased levels of IgM and IgG anti-nucleic antibodies and anti-nucleosome IgG after pristane injection

hematopoietic system

decreased B cell apoptosis ( J:307345 )

• in germinal center after pristane injection

cellular

decreased B cell apoptosis ( J:307345 )

• in germinal center after pristane injection