Phenotypes associated with this allele

• Allele Symbol: Hecw2^tm1.1Fhe
• Allele Name: targeted mutation 1.1, Fuchu He
• Allele ID: MGI:6720293
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hecw2^tm1.1Fhe/Hecw2^tm1.1Fhe	involves: C57BL/6J	MGI:6720335

Genotype
MGI:6720335

hm1

• Allelic Composition: Hecw2^tm1.1Fhe/Hecw2^tm1.1Fhe
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:306367 )

• all mice die within 2 weeks of age

digestive/alimentary system

abnormal intestine morphology ( J:306367 )

• distended and filled with air

• however, mice exhibit normal colon length

decreased small intestine length ( J:306367 )

impaired gastric peristalsis ( J:306367 )

• however, intestinal transit is normal

growth/size/body

decreased body size ( J:306367 )

• beginning at P6

decreased body weight ( J:306367 )

• beginning at P6

nervous system

decreased neuronal precursor proliferation ( J:306367 )

• of enteric nervous system precursors

abnormal myenteric nerve plexus morphology ( J:306367 )

• hypoplastic

cellular

decreased neuronal precursor proliferation ( J:306367 )

• of enteric nervous system precursors