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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trim23em1Phua
endonuclease-mediated mutation 1, Pingbo Huang
MGI:6719577
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trim23em1Phua/Trim23em1Phua involves: C57BL/6 MGI:7627118


Genotype
MGI:7627118
hm1
Allelic
Composition		 Trim23em1Phua/Trim23em1Phua
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trim23em1Phua mutation (0 available); any Trim23 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
increased heart rate ( J:306292 )
• average heart rate is increased by ~21% to 481 beats/min

behavior/neurological
increased chemical nociceptive threshold ( J:306292 )
• total licking time is halved following capsaicin injection
• however, mechanical pain sensation in the von Frey filament assay is similar to controls

digestive/alimentary system
digestive/alimentary phenotype ( J:306292 )
N
• no change in pilocarpine stimulated salivation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory