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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cyrenem1Vokh
endonuclease-mediated mutation 1, Valentyn Oksenych
MGI:6719563
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cyrenem1Vokh/Cyrenem1Vokh C57BL/6-Cyrenem1Vokh MGI:6719592


Genotype
MGI:6719592
hm1
Allelic
Composition		 Cyrenem1Vokh/Cyrenem1Vokh
Genetic
Background		 C57BL/6-Cyrenem1Vokh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyrenem1Vokh mutation (0 available); any Cyren mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal class switch recombination ( J:306598 )
• reduced IgG1 class switch recombination

nervous system
decreased neuronal precursor proliferation ( J:306598 )
• reduced neurosphere proliferation
• however, neuronal stem progenitor cells self-renewal capacity is normal

hematopoietic system
abnormal class switch recombination ( J:306598 )
• reduced IgG1 class switch recombination

cellular
decreased neuronal precursor proliferation ( J:306598 )
• reduced neurosphere proliferation
• however, neuronal stem progenitor cells self-renewal capacity is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory