Phenotypes associated with this allele

• Allele Symbol: Igs2^{em1(Alb-Golm1)Jdon}
• Allele Name: endonuclease-mediated mutation 1, Jian Dong
• Allele ID: MGI:6718455
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Igs2^em1(Alb-Golm1)Jdon/Igs2^+	involves: C57BL/6N	MGI:6718457

Genotype
MGI:6718457

ht1

• Allelic Composition: Igs2^{em1(Alb-Golm1)Jdon}/Igs2⁺
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:306528 )

♂ • mice show a higher hepatocellular carcinoma incidence, heavier liver to body weight ratio and larger tumor diameter following induction with DEN/CCl4

♂ • DEN/CCl4-induced mice show a reduction in CD8+ T cell numbers and an induction of tumor-associated macrophages in tumors

increased susceptibility to injury ( J:306528 )

♂ • in a CCl4-induced liver injury model, mice show more severe inflammation, liver function injury, and liver fibrosis than wild-type mice

neoplasm

increased incidence of tumors by chemical induction ( J:306528 )

♂ • mice show a higher hepatocellular carcinoma incidence, heavier liver to body weight ratio and larger tumor diameter following induction with DEN/CCl4

♂ • DEN/CCl4-induced mice show a reduction in CD8+ T cell numbers and an induction of tumor-associated macrophages in tumors

immune system

decreased CD8-positive, alpha-beta T cell number ( J:306528 )

♂ • DEN/CCl4-induced mice show a reduction in CD8+ T cell numbers

♂ • however, no changes in percentages of other immune cells, including regulatory T cells, CD4+ T cells, B cells, and natural killer cells are seen in DEN/CCl4-induced mice

hematopoietic system

decreased CD8-positive, alpha-beta T cell number ( J:306528 )

♂ • DEN/CCl4-induced mice show a reduction in CD8+ T cell numbers

♂ • however, no changes in percentages of other immune cells, including regulatory T cells, CD4+ T cells, B cells, and natural killer cells are seen in DEN/CCl4-induced mice