About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Setd4tm1b(KOMP)Wtsi
targeted mutation 1b, Wellcome Trust Sanger Institute
MGI:6715241
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Setd4tm1b(KOMP)Wtsi/Setd4tm1b(KOMP)Wtsi involves: C57BL/6N MGI:7627102


Genotype
MGI:7627102
hm1
Allelic
Composition		 Setd4tm1b(KOMP)Wtsi/Setd4tm1b(KOMP)Wtsi
Genetic
Background		 involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Setd4tm1b(KOMP)Wtsi mutation (0 available); any Setd4 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased macrophage cytokine production ( J:304151 )
• bone marrow derived macrophages show reduced IL6 and TNF alpha expression in response to LPS, BLP, or Poly(I:C) stimulation
• expression of a broad range of inflammatory cytokines is reduced

hematopoietic system
decreased macrophage cytokine production ( J:304151 )
• bone marrow derived macrophages show reduced IL6 and TNF alpha expression in response to LPS, BLP, or Poly(I:C) stimulation
• expression of a broad range of inflammatory cytokines is reduced




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/21/2024
MGI 6.23 		The Jackson Laboratory