Phenotypes associated with this allele

• Allele Symbol: Snord115^em1Jcav
• Allele Name: endonuclease-mediated mutation 1, Jerome Cavaille
• Allele ID: MGI:6714008
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Snord115^em1Jcav/Snord115^+	B6.Cg-Snord115^em1Jcav	MGI:6714049

Genotype
MGI:6714049

ht1

• Allelic Composition: Snord115^em1Jcav/Snord115⁺
• Genetic Background: B6.Cg-Snord115^em1Jcav

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

maternal imprinting ( J:305741 )

• all heterozygotes carry a paternally inherited mutant allele

behavior/neurological

behavior/neurological phenotype ( J:305741 )

N • mice with the paternally inherited deletion are seemingly normal, show normal emotional responses when exposed to various acute stressors, normal exploration and sociability, normal food intake

abnormal depression-related behavior ( J:305741 )

• mice with the paternally inherited deletion show an increase in latency to feed compared to wild-type mice in the novelty-suppressed feeding test

• however, mice show normal behavior in the elevated plus maze, tail suspension test and forced swim test, indicating that overall, depression-related behavior is not hugely altered

adipose tissue

increased brown adipose tissue amount ( J:305741 )

• mice fed a high-fat diet show 38% heavier brown adipose tissue than in wild-type mice when the deletion is paternally inherited

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:305741 )

N • mice with the paternally inherited deletion show normal spontaneous food intake and energy balance on chow diet, normal response upon food deprivation, normal ability to regulate a glucose load, and respond normally to the appetite-suppressant actions of the HTR2C agonist mCPP

N • mice fed a high-fat diet show normal weight gain, adiposity, glucose metabolism, food intake, ambulatory activities, energy expenditure and respiratory rate ratio