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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mmrn2tm1Monm
targeted mutation 1, Maurizio Mongiat
MGI:6711429
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mmrn2tm1Monm/Mmrn2tm1Monm involves: C57BL/6NCrl MGI:6711430


Genotype
MGI:6711430
hm1
Allelic
Composition		 Mmrn2tm1Monm/Mmrn2tm1Monm
Genetic
Background		 involves: C57BL/6NCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmrn2tm1Monm mutation (0 available); any Mmrn2 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal retina blood vessel morphology ( J:298039 )
• retinal vessels show abnormal VE-cadherin distribution, frequent indistinguishable endothelial cell contacts, and impaired pericyte coverage
abnormal tumor vascularization ( J:298039 )
• increase in the density of small vessels in B16F10 melanoma cell tumors
increased vascular permeability ( J:298039 )
• in retinal blood vessels and in vessels in B16F10 melanoma cell tumors

neoplasm
abnormal tumor vascularization ( J:298039 )
• increase in the density of small vessels in B16F10 melanoma cell tumors

vision/eye
abnormal retina blood vessel morphology ( J:298039 )
• retinal vessels show abnormal VE-cadherin distribution, frequent indistinguishable endothelial cell contacts, and impaired pericyte coverage




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory