About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mmdtm1Beij
targeted mutation 1, Chinese Academy of Sciences
MGI:6696444
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mmdtm1Beij/Mmdtm1Beij Not Specified MGI:6696445


Genotype
MGI:6696445
hm1
Allelic
Composition
Mmdtm1Beij/Mmdtm1Beij
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmdtm1Beij mutation (0 available); any Mmd mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• thioglycolate-injected mice exhibit less of an increase in peritoneal Ly6C-F4/80+ macrophage compared with similarly treated wild-type mice
• reduced mature macrophage in M-CSF-treated mice than in similarly treated wild-type mice
• however, macrophage polarization is normal
• in mice treated with chicken type II collagen
• mice treated with chicken type II collagen exhibit reduced clinical scores of arthritis and reduced symptoms with reduced tissue damage and inflammation compared with similarly treated wild-type mice

skeleton
• mice treated with chicken type II collagen exhibit reduced clinical scores of arthritis and reduced symptoms with reduced tissue damage and inflammation compared with similarly treated wild-type mice

cellular
• thioglycolate-injected mice exhibit less of an increase in peritoneal Ly6C-F4/80+ macrophage compared with similarly treated wild-type mice
• reduced mature macrophage in M-CSF-treated mice than in similarly treated wild-type mice
• however, macrophage polarization is normal

hematopoietic system
• thioglycolate-injected mice exhibit less of an increase in peritoneal Ly6C-F4/80+ macrophage compared with similarly treated wild-type mice
• reduced mature macrophage in M-CSF-treated mice than in similarly treated wild-type mice
• however, macrophage polarization is normal





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
05/07/2024
MGI 6.23
The Jackson Laboratory