Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snrnp40em1Btlr mutation
(0 available);
any
Snrnp40 mutation
(52 available)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snrnp40em1Btlr mutation
(0 available);
any
Snrnp40 mutation
(52 available)
Snrnp40em2Btlr mutation
(0 available);
any
Snrnp40 mutation
(52 available)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snrnp40em1Btlr mutation
(0 available);
any
Snrnp40 mutation
(52 available)
Snrnp40swp mutation
(0 available);
any
Snrnp40 mutation
(52 available)
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mortality/aging
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• in mice infected with murine cytomegalovirus (MCMV) or herpes simplex virus type 1 (HSV-1)
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immune system
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N |
• mice exhibit normal numbers of neutrophil, eosinophil, basophil, macrophage, and neutrophil numbers, and normal antigen-specific T cell proliferation, T-dependent and T-independent antibody responses, and cytotoxic T lymphocyte (CTL) activity
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• T cells exhibit defective cell cycle progression unlike in wild-type mice
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• blocked at the CD4-CD8- double negative stage and CD4+CD8+ double-positive stage
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• in the spleen and lymph nodes
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• in the spleen and lymph nodes
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• reduced CD3+, CD4+ and CD8+ T cells
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• in an in vivo assay
• however, NK cells treated with phorbol myristate acetate (PMA)/ionomycin exhibit normal degranulation, granzyme B release, and tumor necrosis factor and IFN-gamma production
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• in response to homeostatic expansion signals after transfer into irradiated wild-type mice, CD4+ T cells fail to proliferate and undergo apoptosis unlike wild-type mice
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• in response to homeostatic expansion signals after transfer into irradiated wild-type mice, CD8+ T cells fail to proliferate and undergo apoptosis unlike wild-type mice
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• in mice infected with murine cytomegalovirus (MCMV)
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• in mice infected with murine cytomegalovirus (MCMV)
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• in mice infected with murine cytomegalovirus (MCMV)
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• in mice infected with murine cytomegalovirus (MCMV)
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• in mice infected with murine cytomegalovirus (MCMV)
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• in mice infected with murine cytomegalovirus (MCMV)
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• mice infected with murine cytomegalovirus (MCMV) or herpes simplex virus type 1 (HSV-1) exhibit increased viral titers in the spleen and liver, increased serum cytokine concentrations (Il6, Il12p70, TNF, IFNbeta, IFNgamma, and Il17a), and increased mortality compared with wild-type mice
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• in mice infected with murine cytomegalovirus (MCMV) or herpes simplex virus type 1 (HSV-1)
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pigmentation
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• mice exhibit some white back hairs and white belly spots unlike control mice
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growth/size/body
homeostasis/metabolism
cellular
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• T cells exhibit defective cell cycle progression unlike in wild-type mice
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endocrine/exocrine glands
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• blocked at the CD4-CD8- double negative stage and CD4+CD8+ double-positive stage
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hematopoietic system
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• T cells exhibit defective cell cycle progression unlike in wild-type mice
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• blocked at the CD4-CD8- double negative stage and CD4+CD8+ double-positive stage
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• reduced multipotent progenitor, mild reduction in megakaryocyte-erythroid progenitors, mild increase in granulocyte-macrophage progenitors
• however, mice exhibit normal numbers of long- and short-term hematopoietic stem cell numbers and common myeloid progenitors
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• however, mean platelet volume is normal
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• in the spleen and lymph nodes
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• in the spleen and lymph nodes
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• reduced CD3+, CD4+ and CD8+ T cells
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• in an in vivo assay
• however, NK cells treated with phorbol myristate acetate (PMA)/ionomycin exhibit normal degranulation, granzyme B release, and tumor necrosis factor and IFN-gamma production
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• in response to homeostatic expansion signals after transfer into irradiated wild-type mice, CD4+ T cells fail to proliferate and undergo apoptosis unlike wild-type mice
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• in response to homeostatic expansion signals after transfer into irradiated wild-type mice, CD8+ T cells fail to proliferate and undergo apoptosis unlike wild-type mice
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integument
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• mice exhibit some white back hairs and white belly spots unlike control mice
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Analysis Tools