Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snrnp40swp mutation
(0 available);
any
Snrnp40 mutation
(52 available)
|
|
|
growth/size/body
integument
|
• mice exhibit some white back hairs and white belly spots unlike control mice
|
pigmentation
|
• mice exhibit some white back hairs and white belly spots unlike control mice
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snrnp40em1Btlr mutation
(0 available);
any
Snrnp40 mutation
(52 available)
Snrnp40swp mutation
(0 available);
any
Snrnp40 mutation
(52 available)
|
|
|
mortality/aging
|
• in mice infected with murine cytomegalovirus (MCMV) or herpes simplex virus type 1 (HSV-1)
|
immune system
N |
• mice exhibit normal numbers of neutrophil, eosinophil, basophil, macrophage, and neutrophil numbers, and normal antigen-specific T cell proliferation, T-dependent and T-independent antibody responses, and cytotoxic T lymphocyte (CTL) activity
|
|
• T cells exhibit defective cell cycle progression unlike in wild-type mice
|
|
• blocked at the CD4-CD8- double negative stage and CD4+CD8+ double-positive stage
|
|
• in the spleen and lymph nodes
|
|
• in the spleen and lymph nodes
|
|
• reduced CD3+, CD4+ and CD8+ T cells
|
|
• in an in vivo assay
• however, NK cells treated with phorbol myristate acetate (PMA)/ionomycin exhibit normal degranulation, granzyme B release, and tumor necrosis factor and IFN-gamma production
|
|
• in response to homeostatic expansion signals after transfer into irradiated wild-type mice, CD4+ T cells fail to proliferate and undergo apoptosis unlike wild-type mice
|
|
• in response to homeostatic expansion signals after transfer into irradiated wild-type mice, CD8+ T cells fail to proliferate and undergo apoptosis unlike wild-type mice
|
|
• in mice infected with murine cytomegalovirus (MCMV)
|
|
• in mice infected with murine cytomegalovirus (MCMV)
|
|
• in mice infected with murine cytomegalovirus (MCMV)
|
|
• in mice infected with murine cytomegalovirus (MCMV)
|
|
• in mice infected with murine cytomegalovirus (MCMV)
|
|
• in mice infected with murine cytomegalovirus (MCMV)
|
|
• mice infected with murine cytomegalovirus (MCMV) or herpes simplex virus type 1 (HSV-1) exhibit increased viral titers in the spleen and liver, increased serum cytokine concentrations (Il6, Il12p70, TNF, IFNbeta, IFNgamma, and Il17a), and increased mortality compared with wild-type mice
|
|
• in mice infected with murine cytomegalovirus (MCMV) or herpes simplex virus type 1 (HSV-1)
|
pigmentation
|
• mice exhibit some white back hairs and white belly spots unlike control mice
|
growth/size/body
homeostasis/metabolism
cellular
|
• T cells exhibit defective cell cycle progression unlike in wild-type mice
|
endocrine/exocrine glands
|
• blocked at the CD4-CD8- double negative stage and CD4+CD8+ double-positive stage
|
hematopoietic system
|
• T cells exhibit defective cell cycle progression unlike in wild-type mice
|
|
• blocked at the CD4-CD8- double negative stage and CD4+CD8+ double-positive stage
|
|
• reduced multipotent progenitor, mild reduction in megakaryocyte-erythroid progenitors, mild increase in granulocyte-macrophage progenitors
• however, mice exhibit normal numbers of long- and short-term hematopoietic stem cell numbers and common myeloid progenitors
|
|
• however, mean platelet volume is normal
|
|
• in the spleen and lymph nodes
|
|
• in the spleen and lymph nodes
|
|
• reduced CD3+, CD4+ and CD8+ T cells
|
|
• in an in vivo assay
• however, NK cells treated with phorbol myristate acetate (PMA)/ionomycin exhibit normal degranulation, granzyme B release, and tumor necrosis factor and IFN-gamma production
|
|
• in response to homeostatic expansion signals after transfer into irradiated wild-type mice, CD4+ T cells fail to proliferate and undergo apoptosis unlike wild-type mice
|
|
• in response to homeostatic expansion signals after transfer into irradiated wild-type mice, CD8+ T cells fail to proliferate and undergo apoptosis unlike wild-type mice
|
integument
|
• mice exhibit some white back hairs and white belly spots unlike control mice
|