All Phenotypes Igh<tm3(IGH)Vlcg> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Igh^tm3(IGH)Vlcg
targeted mutation 3, Velocigene
MGI:6696097

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igh^tm3(IGH)Vlcg/Igh^tm3(IGH)Vlcg	involves: 129S6/SvEvTac * C57BL/6NTac	MGI:6696142

Allelic Composition	Igh^tm3(IGH)Vlcg/Igh^tm3(IGH)Vlcg
Genetic Background	involves: 129S6/SvEvTac * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh^tm3(IGH)Vlcg mutation (0 available); any Igh mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:277644 )

N	• female mice exhibit normal fertility • male mice exhibit normal mating behavior and reproductive tissue morphology with normal sperm counts and motility

• severely limited sperm passage from the uterus to the oviduct due to reduced sperm to sperm adhesion

decreased litter size ( J:277644 )

• 4 males only produce 2 litters totaling 4 pups in 6 months

reduced male fertility ( J:277644 )

• severely reduced with 4 males only producing 2 litters totaling 4 pups in 6 months

impaired fertilization ( J:277644 )

• small reduction in sperm binding to cumulus-intact oocytes

• impaired binding to the zona pellucida

cellular

• severely limited sperm passage from the uterus to the oviduct due to reduced sperm to sperm adhesion

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/14/2024 MGI 6.23