Phenotypes associated with this allele

• Allele Symbol: Tg(H2-L^d)LoxNibl
• Allele Name: transgene insertion Lox, Nicolas Blanchard
• Allele ID: MGI:6696066
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tg(Camk2a-cre)2Gsc/0 Tg(H2-L^d)LoxNibl/0	involves: C57BL/6 * FVB/N	MGI:6696113
tg2	Tg(H2-L^d)LoxNibl/0	C57BL/6-Tg(H2-L^d)LoxNibl	MGI:6696112

Genotype
MGI:6696113

cn1

• Allelic Composition: Tg(Camk2a-cre)2Gsc/0; Tg(H2-L^d)LoxNibl/0
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:284394 )

N • normal lack of parasite control (high parasite burden and cyst numbers) in brain after infection with Toxoplasma gondii strain 76K

Genotype
MGI:6696112

tg2

• Allelic Composition: Tg(H2-L^d)LoxNibl/0
• Genetic Background: C57BL/6-Tg(H2-L^d)LoxNibl

immune system

decreased susceptibility to parasitic infection induced morbidity/mortality ( J:284394 )

• lower parasite burden and cyst numbers in brain after infection with Toxoplasma gondii strain 76K

increased response to antigen ( J:284394 )

• robust CD8+ T cell response to Toxoplasma gondii GRA6-derived HF10 (HPGSVNEFDF) peptide in spleen and brain

• lower parasite burden and cyst numbers in brain after infection with Toxoplasma gondii strain 76K

mortality/aging

decreased susceptibility to parasitic infection induced morbidity/mortality ( J:284394 )

• lower parasite burden and cyst numbers in brain after infection with Toxoplasma gondii strain 76K