Phenotypes associated with this allele

• Allele Symbol: Eid1^em1Gpt
• Allele Name: endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
• Allele ID: MGI:6695793
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Eid1^em1Gpt/Eid1^em1Gpt	C57BL/6JGpt-Eid1^em1Gpt/Gpt	MGI:6695797

Genotype
MGI:6695797

hm1

• Allelic Composition: Eid1^em1Gpt/Eid1^em1Gpt
• Genetic Background: C57BL/6JGpt-Eid1^em1Gpt/Gpt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:291224 )

• lower neonatal survival rate

behavior/neurological

impaired spatial learning ( J:291224 )

• mice lack the ability to learn to use the available visual and spatial cues to locate the submerged platform after training in the Morris water maze, showing longer escape latency, longer escape path to locate the platform, less frequency of crossing the platform area after removal of the platform and a shorter period in platform quadrant

increased grooming behavior ( J:291224 )

• mice exhibit more repetitive movements during self-grooming

social withdrawal ( J:291224 )

• adult mice often curl up or stay still in the corner of the cage alone, lacking communication with each other

nervous system

abnormal telencephalon morphology ( J:291224 )

• volume of the telencephalon is smaller at P0

decreased neuronal stem cell self-renewal ( J:291224 )

• neural stem cells show slower proliferation rate when grown in culture; neurospheres are smaller, fewer number of spheres are seen, and within 7 days of cell culture, the growth rate of the neurospheres is slower