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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tmem175em3Dren
endonuclease-mediated mutation 3, Dejian Ren
MGI:6695108
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tmem175em3Dren/Tmem175em3Dren C57BL/6J-Tmem175em3Dren MGI:6695117
ht2
 		Tmem175em3Dren/Tmem175+ C57BL/6J-Tmem175em3Dren MGI:6695120


Genotype
MGI:6695117
hm1
Allelic
Composition		 Tmem175em3Dren/Tmem175em3Dren
Genetic
Background		 C57BL/6J-Tmem175em3Dren
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmem175em3Dren mutation (0 available); any Tmem175 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased susceptibility to neuronal excitotoxicity ( J:304120 )
• midbrain neurons show much more damage in response to the neurotoxin MPTP
abnormal lysosome physiology ( J:304120 )
• lysosomal K+ currents are reduced in midbrain neurons

homeostasis/metabolism
increased susceptibility to neuronal excitotoxicity ( J:304120 )
• midbrain neurons show much more damage in response to the neurotoxin MPTP

nervous system
increased susceptibility to neuronal excitotoxicity ( J:304120 )
• midbrain neurons show much more damage in response to the neurotoxin MPTP
alpha-synuclein inclusion body ( J:304120 )
• in an in vitro transmission model in which alpha-synuclein preformed fibrils are used to seed endogenous alpha-synuclein into Lewy-like inclusions, neurons accumulate increased alpha-synuclein phosphorylated at S129 2 weeks after exposure compared to wild-type neurons; this accumulation of alpha-synuclein leads to increased damage to the integrity of lysosomal membranes in neurons




Genotype
MGI:6695120
ht2
Allelic
Composition		 Tmem175em3Dren/Tmem175+
Genetic
Background		 C57BL/6J-Tmem175em3Dren
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmem175em3Dren mutation (0 available); any Tmem175 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased susceptibility to neuronal excitotoxicity ( J:304120 )
• midbrain neurons show much more damage in response to the neurotoxin MPTP
abnormal lysosome physiology ( J:304120 )
• lysosomal K+ currents are reduced in midbrain neurons

homeostasis/metabolism
increased susceptibility to neuronal excitotoxicity ( J:304120 )
• midbrain neurons show much more damage in response to the neurotoxin MPTP

nervous system
increased susceptibility to neuronal excitotoxicity ( J:304120 )
• midbrain neurons show much more damage in response to the neurotoxin MPTP
alpha-synuclein inclusion body ( J:304120 )
• in an in vitro transmission model in which alpha-synuclein preformed fibrils are used to seed endogenous alpha-synuclein into Lewy-like inclusions, neurons accumulate increased alpha-synuclein phosphorylated at S129 2 weeks after exposure compared to wild-type neurons; this accumulation of alpha-synuclein leads to increased damage to the integrity of lysosomal membranes in neurons




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory