Phenotypes associated with this allele

• Allele Symbol: Cabs1^em1Ntu
• Allele Name: endonuclease-mediated mutation 1, Comparative Medicine Research Center of Nantong University
• Allele ID: MGI:6694874
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cabs1^em1Ntu/Cabs1^em1Ntu	C57BL/6-Cabs1^em1Ntu	MGI:6694878

Genotype
MGI:6694878

hm1

• Allelic Composition: Cabs1^em1Ntu/Cabs1^em1Ntu
• Genetic Background: C57BL/6-Cabs1^em1Ntu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal sperm annulus morphology ( J:304106 )

♂ • thinning in spermatozoa

♂ • however, CRISPR-targeting of the anti-sense transcript does not alter sperm morphology

absent sperm annulus ( J:304106 )

♂ • in sperm

kinked sperm flagellum ( J:304106 )

♂ • increasing in proportion as sperm transit in the epididymis

asthenozoospermia ( J:304106 )

♂ • in some mice

♂ • however, CRISPR-targeting of the reverse strand anti-sense transcript does not alter sperm motility

reduced male fertility ( J:304106 )

♂ • reduced pregnancy rates

♂ • however, fertility is normal in some mice and litter size is normal overall

cellular

abnormal sperm annulus morphology ( J:304106 )

♂ • thinning in spermatozoa

♂ • however, CRISPR-targeting of the anti-sense transcript does not alter sperm morphology

absent sperm annulus ( J:304106 )

♂ • in sperm

kinked sperm flagellum ( J:304106 )

♂ • increasing in proportion as sperm transit in the epididymis

asthenozoospermia ( J:304106 )

♂ • in some mice

♂ • however, CRISPR-targeting of the reverse strand anti-sense transcript does not alter sperm motility