Phenotypes associated with this allele

• Allele Symbol: Colgalt1^tm1.1Gpt
• Allele Name: targeted mutation 1, GemPharmatech, Co., Ltd
• Allele ID: MGI:6694288
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Colgalt1^tm1.1Gpt/Colgalt1^tm1.1Gpt	Not Specified	MGI:6694289
ht2	Colgalt1^tm1.1Gpt/Colgalt1^+	Not Specified	MGI:6694290

Genotype
MGI:6694289

hm1

• Allelic Composition: Colgalt1^tm1.1Gpt/Colgalt1^tm1.1Gpt
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:283330 )

• no embryos are found after E11.5

embryo

placenta hemorrhage ( J:283330 )

• in the labyrinth zone

embryonic growth retardation ( J:283330 )

abnormal embryo morphology ( J:283330 )

• appear small, soft, and pale at E11.5

decreased embryo size ( J:283330 )

• at E9.5, E10.5, and E11.5

decreased embryonic neuroepithelium thickness ( J:283330 )

abnormal placenta morphology ( J:283330 )

abnormal placental labyrinth vasculature morphology ( J:283330 )

• disorganized

placenta necrosis ( J:283330 )

• multifocal necrosis in the labyrinth zone

abnormal placenta junctional zone morphology ( J:283330 )

• decreased thickness

abnormal placenta intervillous maternal lacunae morphology ( J:283330 )

• number of invading maternal blood sinuses is strongly decreased

thin placenta labyrinth ( J:283330 )

abnormal placenta development ( J:283330 )

• expression analysis indicates impaired placental angiogenesis

nervous system

decreased embryonic neuroepithelium thickness ( J:283330 )

liver/biliary system

decreased hepatocyte proliferation ( J:283330 )

• at E10.5

abnormal hepatocyte morphology ( J:283330 )

• array of hepatocytes is disordered and there is an increase in empty spaces indicating a decrease in parenchymal hepatocyte density

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:283330 )

• disorganized

placenta hemorrhage ( J:283330 )

• in the labyrinth zone

growth/size/body

embryonic growth retardation ( J:283330 )

decreased embryo size ( J:283330 )

• at E9.5, E10.5, and E11.5

cellular

placenta necrosis ( J:283330 )

• multifocal necrosis in the labyrinth zone

decreased hepatocyte proliferation ( J:283330 )

• at E10.5

Genotype
MGI:6694290

ht2

• Allelic Composition: Colgalt1^tm1.1Gpt/Colgalt1⁺
• Genetic Background: Not Specified

embryo

embryonic growth retardation ( J:283330 )

decreased embryo size ( J:283330 )

• smaller than wild-type but larger than homozygous null littermates at E9.5, E10.5 and E11.5

liver/biliary system

abnormal liver physiology ( J:283330 )

• increased susceptibility to CCl4 induced liver injury

growth/size/body

embryonic growth retardation ( J:283330 )

decreased embryo size ( J:283330 )

• smaller than wild-type but larger than homozygous null littermates at E9.5, E10.5 and E11.5

decreased body weight ( J:283330 )

• at weaning

homeostasis/metabolism

increased susceptibility to injury ( J:283330 )

• increased susceptibility to CCl4 induced liver injury