Phenotypes associated with this allele

• Allele Symbol: Ddx18^em1.1Shx
• Allele Name: endonuclease-mediated mutation 1.1, Xiaohua Shen
• Allele ID: MGI:6693739
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ddx18^em1.1Shx/Ddx18^em1.1Shx	involves: C57BL/6J	MGI:6693740

Genotype
MGI:6693740

hm1

• Allelic Composition: Ddx18^em1.1Shx/Ddx18^em1.1Shx
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:287559 )

• at E3.5 - E4.0 embryos appear to arrest at the morula stage and no viable embryos are found at E10.5

embryo

embryonic growth arrest ( J:287559 )

• at E3.5 - E4.0 embryos appear to arrest at the morula stage and fail to form distinct blastocoels

abnormal pluripotent precursor cell morphology ( J:287559 )

• expression analysis indicates a loss of pluripotency in early development