Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1(cre)Uba mutation
(0 available);
any
Aicda mutation
(55 available)
Dis3tm1.1Uba mutation
(0 available);
any
Dis3 mutation
(42 available)
Ightm1Mnz mutation
(4 available);
any
Igh mutation
(43 available)
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immune system
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• mice immunized to induced somatic hypermutation show higher mutation frequencies in germinal center derived B cells
• the C to T mutation frequency is increased and inversely, the G to A mutation frequency is decreased in germinal cell B cells, indicating dysregulation of activation-induced cytidine deaminase activity at the V(D)J exon during somatic hypermutation
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hematopoietic system
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• mice immunized to induced somatic hypermutation show higher mutation frequencies in germinal center derived B cells
• the C to T mutation frequency is increased and inversely, the G to A mutation frequency is decreased in germinal cell B cells, indicating dysregulation of activation-induced cytidine deaminase activity at the V(D)J exon during somatic hypermutation
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dis3tm1.1Uba mutation
(0 available);
any
Dis3 mutation
(42 available)
Gt(ROSA)26Sortm9(cre/ESR1)Arte mutation
(2 available);
any
Gt(ROSA)26Sor mutation
(944 available)
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immune system
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• B cells exhibit altered chromosome architecture genome wide in tamoxifen-treated mice
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• B cells in vitro stimulated with tamoxifen exhibit a defect in class-switch recombination
• tamoxifen-treated B cells show a reduction to class-switch recombination to IgG1
• tamoxifen-treated mice show an increase in microhomology-mediated DNA junctions in B cells
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hematopoietic system
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• B cells exhibit altered chromosome architecture genome wide in tamoxifen-treated mice
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• B cells in vitro stimulated with tamoxifen exhibit a defect in class-switch recombination
• tamoxifen-treated B cells show a reduction to class-switch recombination to IgG1
• tamoxifen-treated mice show an increase in microhomology-mediated DNA junctions in B cells
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Analysis Tools