Phenotypes associated with this allele

• Allele Symbol: Pou4f3^{em1(cre/ERT2)Yss}
• Allele Name: endonuclease-mediated mutation 1, Yun Stone Shi
• Allele ID: MGI:6693366
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pou4f3^em1(cre/ERT2)Yss/Pou4f3^em1(cre/ERT2)Yss	involves: C57BL/6J	MGI:8220075
ht2	Pou4f3^em1(cre/ERT2)Yss/Pou4f3^+	involves: C57BL/6J	MGI:8220077
ht3	Pou4f3^em1(cre/ERT2)Yss/Pou4f3^+	involves: C57BL/6J * FVB/NJ	MGI:8220079
cn4	Pou4f3^em1(cre/ERT2)Yss/Pou4f3^+ Tmem63b^em2Yss/Tmem63b^em2Yss	involves: C57BL/6N	MGI:6693368

Genotype
MGI:8220075

hm1

• Allelic Composition: Pou4f3^{em1(cre/ERT2)Yss}/Pou4f3^{em1(cre/ERT2)Yss}
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

cochlear hair cell degeneration ( J:296699 )

• extensive degeneration at P3

nervous system

cochlear hair cell degeneration ( J:296699 )

• extensive degeneration at P3

Genotype
MGI:8220077

ht2

• Allelic Composition: Pou4f3^{em1(cre/ERT2)Yss}/Pou4f3⁺
• Genetic Background: involves: C57BL/6J

hearing/vestibular/ear

cochlear outer hair cell degeneration ( J:296699 )

• significantly degenerated at 32 kHz at 3 months of age

decreased auditory brainstem response wave amplitude ( J:296699 )

• reduced peak 1 amplitudes at across all frequencies at 3 months of age

increased or absent threshold for auditory brainstem response ( J:296699 )

• increased at 32 kHz at 3 months of age

increased or absent distortion product otoacoustic emission threshold ( J:296699 )

• increased at 32 kHz at 3 months of age

nervous system

cochlear outer hair cell degeneration ( J:296699 )

• significantly degenerated at 32 kHz at 3 months of age

Genotype
MGI:8220079

ht3

• Allelic Composition: Pou4f3^{em1(cre/ERT2)Yss}/Pou4f3⁺
• Genetic Background: involves: C57BL/6J * FVB/NJ

hearing/vestibular/ear

cochlear outer hair cell degeneration ( J:296699 )

• significantly loss at multiple frequencies at 9 months of age

abnormal auditory brainstem response waveform shape ( J:296699 )

• at 9 months of age

increased or absent threshold for auditory brainstem response ( J:296699 )

• at 9 months of age

increased or absent distortion product otoacoustic emission threshold ( J:296699 )

• at 9 months of age

impaired hearing ( J:296699 )

• at 9 months of age

nervous system

cochlear outer hair cell degeneration ( J:296699 )

• significantly loss at multiple frequencies at 9 months of age

Genotype
MGI:6693368

cn4

• Allelic Composition: Pou4f3^{em1(cre/ERT2)Yss}/Pou4f3⁺; Tmem63b^em2Yss/Tmem63b^em2Yss
• Genetic Background: involves: C57BL/6N

hearing/vestibular/ear

cochlear outer hair cell degeneration ( J:303483 )

• in tamoxifen-treated mice

increased or absent threshold for auditory brainstem response ( J:303483 )

• auditory brainstem response thresholds are elevated in tamoxifen-treated mice

abnormal distortion product otoacoustic emission ( J:303483 )

• distortion product otoacoustic emission thresholds are elevated in tamoxifen-treated mice

impaired hearing ( J:303483 )

• tamoxifen-treated mice exhibit hearing loss

nervous system

cochlear outer hair cell degeneration ( J:303483 )

• in tamoxifen-treated mice