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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tmem63bem2Yss
endonuclease-mediated mutation 2, Yun Stone Shi
MGI:6693365
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Pou4f3em1(cre/ERT2)Yss/Pou4f3+
Tmem63bem2Yss/Tmem63bem2Yss 		involves: C57BL/6N MGI:6693368


Genotype
MGI:6693368
cn1
Allelic
Composition		 Pou4f3em1(cre/ERT2)Yss/Pou4f3+
Tmem63bem2Yss/Tmem63bem2Yss
Genetic
Background		 involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pou4f3em1(cre/ERT2)Yss mutation (0 available); any Pou4f3 mutation (26 available)
Tmem63bem2Yss mutation (0 available); any Tmem63b mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
cochlear outer hair cell degeneration ( J:303483 )
• in tamoxifen-treated mice
increased or absent threshold for auditory brainstem response ( J:303483 )
• auditory brainstem response thresholds are elevated in tamoxifen-treated mice
abnormal distortion product otoacoustic emission ( J:303483 )
• distortion product otoacoustic emission thresholds are elevated in tamoxifen-treated mice
impaired hearing ( J:303483 )
• tamoxifen-treated mice exhibit hearing loss

nervous system
cochlear outer hair cell degeneration ( J:303483 )
• in tamoxifen-treated mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory