Phenotypes associated with this allele

• Allele Symbol: Dock11^tm1.1Mmar
• Allele Name: targeted mutation 1.1, Mitsuo Maruyama
• Allele ID: MGI:6690850
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dock11^tm1.1Mmar/Dock11^tm1.1Mmar	Not Specified	MGI:6690856

Genotype
MGI:6690856

hm1

• Allelic Composition: Dock11^tm1.1Mmar/Dock11^tm1.1Mmar
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal thymus cell ratio ( J:238172 )

• increased thymic CD4+ T cell percentage

immune system

immune system phenotype ( J:238172 )

N • normal number of viable B and T cells in bone marrow, spleen, thymus and peritoneal cavi

N • normal spleen and thymus histology

N • normal immune responses against NP-CGG, TNP-LPS and TNP-Ficoll

N • normal marginal metallophilic macrophage (MMM) and marginal zone macrophage (MZM) numbers in spleen

N • normal LPS-induced spleen marginal zone B cell proliferation

N • normal migration of spleen marginal zone B cells towards B lymphocyte chemoattractant (BLC) and SDF-1alpha

abnormal thymus cell ratio ( J:238172 )

• increased thymic CD4+ T cell percentage

abnormal metallophilic macrophage morphology ( J:238172 )

• sparse MMM ring around spleen marginal zone

abnormal spleen marginal zone morphology ( J:238172 )

• narrowing of B cell region (B220+ region outside CD169+ MZ macrophages)

decreased marginal zone B cell number ( J:238172 )

• reduction of percentage of B cells in spleen

hematopoietic system

abnormal thymus cell ratio ( J:238172 )

• increased thymic CD4+ T cell percentage

abnormal metallophilic macrophage morphology ( J:238172 )

• sparse MMM ring around spleen marginal zone

abnormal spleen marginal zone morphology ( J:238172 )

• narrowing of B cell region (B220+ region outside CD169+ MZ macrophages)

decreased marginal zone B cell number ( J:238172 )

• reduction of percentage of B cells in spleen

growth/size/body

growth/size/body region phenotype ( J:238172 )

N • no gross abnormalities

mortality/aging

mortality/aging ( J:238172 )

N • viable

reproductive system

reproductive system phenotype ( J:238172 )

N • fertile