All Phenotypes Jazf1<tm1c(EUCOMM)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Jazf1^{tm1c(EUCOMM)Wtsi}
targeted mutation 1c, Wellcome Trust Sanger Institute
MGI:6690297

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ins2^Akita/Ins2^Akita Jazf1^{tm1c(EUCOMM)Wtsi}/Jazf1^{tm1c(EUCOMM)Wtsi} Tg(Ins2-cre)23Herr/0	involves: 129S4/SvJaeSor * C57BL/6N * C57BL/6NSlc * CBA/J	MGI:6690322
cn2	Jazf1^{tm1c(EUCOMM)Wtsi}/Jazf1^{tm1c(EUCOMM)Wtsi} Tg(Ins2-cre)23Herr/0	involves: 129S4/SvJaeSor * C57BL/6N * CBA/J	MGI:6690320

Allelic Composition	Ins2^Akita/Ins2^Akita Jazf1^{tm1c(EUCOMM)Wtsi}/Jazf1^{tm1c(EUCOMM)Wtsi} Tg(Ins2-cre)23Herr/0
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6N * C57BL/6NSlc * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ins2^Akita mutation (14 available); any Ins2 mutation (90 available)
Jazf1^{tm1c(EUCOMM)Wtsi} mutation (0 available); any Jazf1 mutation (24 available)
Tg(Ins2-cre)23Herr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

increased pancreatic beta cell apoptosis ( J:303318 )

• at age 8 weeks

decreased pancreatic beta cell proliferation ( J:303318 )

• 70% reduction

endocrine/exocrine glands

increased pancreatic beta cell apoptosis ( J:303318 )

• at age 8 weeks

decreased pancreatic beta cell proliferation ( J:303318 )

• 70% reduction

decreased pancreatic beta cell mass ( J:303318 )

• 50% reduction

growth/size/body

growth/size/body region phenotype ( J:303318 )

N	• normal body weight

homeostasis/metabolism

abnormal glucose homeostasis ( J:303318 )

• increased proinsulin levels

increased circulating glucose level ( J:303318 )

Allelic Composition	Jazf1^{tm1c(EUCOMM)Wtsi}/Jazf1^{tm1c(EUCOMM)Wtsi} Tg(Ins2-cre)23Herr/0
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6N * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jazf1^{tm1c(EUCOMM)Wtsi} mutation (0 available); any Jazf1 mutation (24 available)
Tg(Ins2-cre)23Herr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal translation ( J:303318 )

• reduced protein synthesis in pancreatic islets

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:303318 )

N	• normal glucose-induced insulin secretion (GSIS) from isolated pancreatic islets on regular chow and after 12 weeks on high-fat diet (HFD)

decreased pancreatic beta cell mass ( J:303318 )

• at age 16 weeks on regular chow and after 12 weeks on high-fat diet (HFD)

abnormal endocrine pancreas physiology ( J:303318 )

• low pancreatic insulin level at age 16 weeks on regular chow and after 12 weeks on high-fat diet (HFD)

growth/size/body

growth/size/body region phenotype ( J:303318 )

N	• normal body weight on regular chow and after 12 weeks on high-fat diet (HFD)

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:303318 )

N	• normal blood glucose level on regular chow and after 12 weeks on high-fat diet (HFD) • normal glucose-induced insulin secretion (GSIS) from isolated pancreatic islets on regular chow and after 12 weeks on high-fat diet (HFD)

abnormal translation ( J:303318 )

• reduced protein synthesis in pancreatic islets

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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