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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pmfbp1em#Jfw
endonuclease-mediated mutation, Jian-Feng Wu
MGI:6681928
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Pmfbp1em#Jfw/Pmfbp1em#Jfw Not Specified MGI:6681929


Genotype
MGI:6681929
hm1
Allelic
Composition
Pmfbp1em#Jfw/Pmfbp1em#Jfw
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pmfbp1em#Jfw mutation (0 available); any Pmfbp1 mutation (55 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• the microtubule doublets of exoneme are slightly affected
• the mitochondrial sheath is disorganized
• approximately 98% of spermatozoa are acephalic
• males mate normally with females but fail to produce offspring
• however, females produce offspring when mated with wild-type males, indicating normal female fertility
• however, males show no difference in body weight or testis weight or in seminiferous tubule morphology

cellular
• the microtubule doublets of exoneme are slightly affected
• the mitochondrial sheath is disorganized
• approximately 98% of spermatozoa are acephalic

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
spermatogenic failure 31 DOID:0111922 OMIM:618112
J:303070





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory