Phenotypes associated with this allele

• Allele Symbol: Lrrc25^em1Cya
• Allele Name: endonuclease-mediated mutation 1, Cyagen Biosciences
• Allele ID: MGI:6514757
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lrrc25^em1Cya/Lrrc25^em1Cya	C57BL/6J-Lrrc25^em1Cya/Cya	MGI:6514758

Genotype
MGI:6514758

hm1

• Allelic Composition: Lrrc25^em1Cya/Lrrc25^em1Cya
• Genetic Background: C57BL/6J-Lrrc25^em1Cya/Cya

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased response of heart to induced stress ( J:270157 )

• mice subjected to aortic banding develop enhanced cardiac hypertrophy, cardiac fibrosis, cardiac inflammation, and accelerated cardiac dysfunction

abnormal tumor necrosis factor level ( J:270157 )

• cardiomyocytes stimulated with angiotensin II show increased expression of TNF-alpha

increased transforming growth factor beta level ( J:270157 )

• cardiomyocytes stimulated with angiotensin II show higher expression levels of TGF-beta1

cardiovascular system

cardiac hypertrophy ( J:270157 )

• mice subjected to aortic banding exhibit accelerated cardiac hypertrophy compared to controls and show enhanced expression of cardiac hypertrophy markers

• mice subjected to aortic banding exhibit a higher ratio of heart weight to body weight compared to controls

cardiac fibrosis ( J:270157 )

• mice subjected to aortic banding exhibit enhanced collagen accumulation and enhanced expression of fibrosis markers

• cardiomyocytes stimulated with angiotensin II show exacerbated fibrosis compared to control cardiomyocytes

decreased cardiac muscle contractility ( J:270157 )

• mice subjected to aortic banding show decreased left ventricle ejection fraction and left ventricle fractional shortening

increased response of heart to induced stress ( J:270157 )

• mice subjected to aortic banding develop enhanced cardiac hypertrophy, cardiac fibrosis, cardiac inflammation, and accelerated cardiac dysfunction

heart inflammation ( J:270157 )

• marker analysis indicates that aortic banding-induced inflammation is aggravated in mutants

• cardiomyocytes stimulated with angiotensin II show increased expression of TNF-alpha, IL-1beta, and p-NF-kappaB

• pre-treatment with Pirfenidone, a TGF-beta1 inhibitor, diminishes the angiotensin II-induced expression of TGF-beta1, p-NF-kappaB, TNF-alpha, and IL-1beta

• treatment of cardiomyocytes with BAY 11-7082, a suppressor of NF-kappaB activation, diminishes the angiotensin II-induced expression of p-NF-kappaB, TNF-alpha, and IL-1beta

growth/size/body

cardiac hypertrophy ( J:270157 )

• mice subjected to aortic banding exhibit accelerated cardiac hypertrophy compared to controls and show enhanced expression of cardiac hypertrophy markers

• mice subjected to aortic banding exhibit a higher ratio of heart weight to body weight compared to controls

immune system

heart inflammation ( J:270157 )

• marker analysis indicates that aortic banding-induced inflammation is aggravated in mutants

• cardiomyocytes stimulated with angiotensin II show increased expression of TNF-alpha, IL-1beta, and p-NF-kappaB

• pre-treatment with Pirfenidone, a TGF-beta1 inhibitor, diminishes the angiotensin II-induced expression of TGF-beta1, p-NF-kappaB, TNF-alpha, and IL-1beta

• treatment of cardiomyocytes with BAY 11-7082, a suppressor of NF-kappaB activation, diminishes the angiotensin II-induced expression of p-NF-kappaB, TNF-alpha, and IL-1beta

abnormal tumor necrosis factor level ( J:270157 )

• cardiomyocytes stimulated with angiotensin II show increased expression of TNF-alpha

muscle

decreased cardiac muscle contractility ( J:270157 )

• mice subjected to aortic banding show decreased left ventricle ejection fraction and left ventricle fractional shortening