All Phenotypes Nlrp9a<em3Okkm> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nlrp9a^em3Okkm
endonuclease-mediated mutation 3, Tohru Kimura
MGI:6514375

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Nlrp9a^em3Okkm/Nlrp9a^em3Okkm Nlrp9c^em1Okkm/Nlrp9c^em1Okkm	involves: ICR	MGI:6514796
cx2	Nlrp9a^em3Okkm/Nlrp9a^em3Okkm Nlrp9b^em3Okkm/Nlrp9b^em3Okkm Nlrp9c^em3Okkm/Nlrp9c^em3Okkm	involves: ICR	MGI:6514798
cx3	Nlrp9a^em3Okkm/Nlrp9a^em3Okkm Nlrp9b^em3Okkm/Nlrp9b^em3Okkm Nlrp9c^em2Okkm/Nlrp9c^em4Okkm	involves: ICR	MGI:6514799

Allelic Composition	Nlrp9a^em3Okkm/Nlrp9a^em3Okkm Nlrp9c^em1Okkm/Nlrp9c^em1Okkm
Genetic Background	involves: ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp9a^em3Okkm mutation (0 available); any Nlrp9a mutation (73 available)
Nlrp9c^em1Okkm mutation (0 available); any Nlrp9c mutation (67 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal blastocyst formation ( J:302234 )

• small blastocyst

embryonic growth retardation ( J:302234 )

• delayed blastocyst formation

growth/size/body

embryonic growth retardation ( J:302234 )

• delayed blastocyst formation

Allelic Composition	Nlrp9a^em3Okkm/Nlrp9a^em3Okkm Nlrp9b^em3Okkm/Nlrp9b^em3Okkm Nlrp9c^em3Okkm/Nlrp9c^em3Okkm
Genetic Background	involves: ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp9a^em3Okkm mutation (0 available); any Nlrp9a mutation (73 available)
Nlrp9b^em3Okkm mutation (0 available); any Nlrp9b mutation (53 available)
Nlrp9c^em3Okkm mutation (0 available); any Nlrp9c mutation (67 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal blastocyst formation ( J:302234 )

• smaller blastocysts in zygotes that form a blastocyst at E3.5 and E4.5

failure of blastocyst formation ( J:302234 )

• fewer E3.5 mice zygotes develop a blastocyst remaining as morulae or embryos degenerate

failure of zygotic cell division ( J:302234 )

• blocked at the 2-cell stage with asymmetric cell division

embryonic growth retardation ( J:302234 )

• some zygotes do not develop a blastocyst until E4.5

growth/size/body

embryonic growth retardation ( J:302234 )

• some zygotes do not develop a blastocyst until E4.5

mortality/aging

embryonic lethality before implantation, incomplete penetrance ( J:302234 )

• some mice degenerate prior to implantation

reproductive system

long gestation period ( J:302234 )

• slightly

decreased litter size ( J:302234 )

• in female mice crossed with wild-type male mice in addition to more litters with seven or fewer pups compared with wild-type mice

• however, mice have comparable number of deliveries and normal fertilization rates

Allelic Composition	Nlrp9a^em3Okkm/Nlrp9a^em3Okkm Nlrp9b^em3Okkm/Nlrp9b^em3Okkm Nlrp9c^em2Okkm/Nlrp9c^em4Okkm
Genetic Background	involves: ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp9a^em3Okkm mutation (0 available); any Nlrp9a mutation (73 available)
Nlrp9b^em3Okkm mutation (0 available); any Nlrp9b mutation (53 available)
Nlrp9c^em2Okkm mutation (0 available); any Nlrp9c mutation (67 available)
Nlrp9c^em4Okkm mutation (0 available); any Nlrp9c mutation (67 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality before implantation, incomplete penetrance ( J:302234 )

• some mice degenerate prior to implantation

reproductive system

long gestation period ( J:302234 )

• slightly

decreased litter size ( J:302234 )

• in female mice crossed with wild-type male mice in addition to more litters with seven or fewer pups compared with wild-type mice

• however, mice have comparable number of deliveries and normal fertilization rates

embryo

abnormal blastocyst formation ( J:302234 )

• smaller blastocysts in zygotes that form a blastocyst at E3.5 and E4.5

failure of blastocyst formation ( J:302234 )

• fewer E3.5 mice zygotes develop a blastocyst remaining as morulae or embryos degenerate

failure of zygotic cell division ( J:302234 )

• blocked at the 2-cell stage with asymmetric cell division

embryonic growth retardation ( J:302234 )

• some zygotes do not develop a blastocyst until E4.5

growth/size/body

embryonic growth retardation ( J:302234 )

• some zygotes do not develop a blastocyst until E4.5

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